Chemoreflex and metaboreflex responses to static hypoxic exercise in aging humans

Medicine and Science in Sports and Exercise
Anne HoussierePhilippe Van De Borne

Abstract

We tested the hypothesis that aging decreases the contribution of metaboreceptors to sympathetic responses during exercise in hypoxia. We recorded sympathetic nerve traffic to muscle circulation (MSNA), heart rate (HR), blood pressure (BP), minute ventilation (VE), and blood lactate (BL) in 12 older (55 +/- 10 yr) and 12 younger (22 +/- 2 yr) normal subjects during three randomized interventions: isocapnic hypoxia (chemoreflex activation), isometric handgrip exercise (HG) in normoxia (metaboreflex activation), and HG during isocapnic hypoxia (concomitant metaboreflex and chemoreflex activation). All interventions were followed by a forearm circulatory arrest period to allow metaboreflex activation in the absence of exercise and chemoreflex activation. Older subjects had higher resting MSNA (38 +/- 12 vs 23 +/- 9 bursts per minute; P < 0.01) and BP (P < 0.001). Heart rate, minute ventilation, and blood lactate did not differ (all P > 0.5). MSNA responses to HG in normoxia (P < 0.05) and in hypoxia (P < 0.05) were smaller in the older subjects, but were similar during hypoxia alone. The increase in HR was smaller in the older subjects for all interventions (all P < 0.05). In contrast, the increase in systolic and diastolic BP, VE...Continue Reading

References

Sep 1, 1991·Journal of Applied Physiology·D R SealsR F Fregosi
Jan 1, 1991·The Japanese Journal of Physiology·M SaitoT Mano
Jan 1, 1989·Respiration; International Review of Thoracic Diseases·M Tafil-KlaweP von Wichert
Jun 1, 1988·Journal of Applied Physiology·D M Rotto, M P Kaufman
Oct 1, 1988·The Journal of Clinical Investigation·R G VictorR L Nunnally
Oct 1, 1987·Clinical Physiology·L B Rowell, J R Blackmon
Aug 1, 1973·The Journal of Clinical Investigation·R S Kronenberg, C W Drage
Jan 1, 1972·Acta Physiologica Scandinavica·W DeliusB G Wallin
Oct 1, 1971·Cardiovascular Research·J ConwayR Sannerstedt
Nov 1, 1993·Journal of Applied Physiology·M J PoulinW D Smith
Sep 11, 2002·Circulation·Frank A DinennoMichael J Joyner
Nov 2, 2002·The Journal of Physiology·Masashi IchinoseTakeshi Nishiyasu
Feb 13, 2003·Circulation·Troy A MarkelLawrence I Sinoway
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sonia Velez-RoaPhilippe van de Borne
Oct 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thad E WilsonChester A Ray
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Anne HoussierePhilippe van de Borne

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Citations

Nov 26, 2013·Journal of Science and Medicine in Sport·Justin Wee, Mike Climstein
Feb 22, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Matthew D MullerLawrence I Sinoway
Jul 29, 2011·European Journal of Applied Physiology·Paulo J C VieiraGaspar R Chiappa
Jul 29, 2011·European Journal of Applied Physiology·K KrzemińskiK Nazar
Feb 14, 2012·Heart Failure Reviews·Tissa Kappagoda, Ezra A Amsterdam
Aug 19, 2007·Clinical Physiology and Functional Imaging·Bruno T RoseguiniJorge P Ribeiro
Jun 5, 2013·Experimental Physiology·Jody L GreaneyWilliam B Farquhar
Oct 6, 2009·Experimental Physiology·Christos K LykidisGeorge M Balanos
Aug 29, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E F BakkeE Stranden
Aug 1, 2016·Sports Medicine·Billy SperlichJennifer Wegrzyk
Aug 1, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catherine F NotariusJohn S Floras
Aug 12, 2014·Journal of Applied Physiology·Jody L GreaneyLacy M Alexander
Nov 17, 2012·Journal of Applied Physiology·Matthew D MullerLawrence I Sinoway
Dec 18, 2013·Journal of Applied Physiology·Sophie LalandeJ Kevin Shoemaker
Feb 27, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Joshua R SmithCraig A Harms
Feb 6, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer C RichardsFrank A Dinenno
Sep 20, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Simranjit K SidhuMarkus Amann
Feb 21, 2019·European Journal of Applied Physiology·Gabriele MulliriAntonio Crisafulli
Aug 10, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Adrian LisBartłomiej Paleczny
Feb 28, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H Edgell, M K Stickland
Apr 8, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Evan L MatthewsWilliam B Farquhar
Nov 30, 2018·Frontiers in Aging Neuroscience·Guillaume CaronTanguy Marqueste
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Anne HoussierePhilippe van de Borne

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