PMID: 7541631Jun 1, 1995Paper

Chemorepulsion of developing motor axons by the floor plate

Neuron
S Guthrie, A Pini

Abstract

In the developing nervous system, motor axons grow away from the ventral midline floor plate, suggesting that the latter might be a source of repulsive axonal guidance cues. In donor to host transplantation experiments, ectopic pieces of floor plate were positioned between chick hindbrain motor neurons and their exit points. Immunohistochemistry and retrograde axonal labeling techniques demonstrated that motor axons diverted from their normal pathways to avoid grafted floor plate, often traversing abnormally long circuitous trajectories to reach exit points. When ventral explants of rat hindbrain and spinal cord were cocultured at a distance from floor plate explants within collagen gel matrices, the outgrowth of motor axons was dramatically reduced from explant borders that faced the floor plate. Thus, the floor plate secretes diffusible repulsive cues in vitro that may exclude motor axons from the midline during development.

References

Aug 1, 1990·Trends in Neurosciences·A Lumsden
May 8, 1991·The Journal of Comparative Neurology·A Prasad, M Hollyday
Aug 1, 1990·Development·O PourquiéN M Le Douarin
Feb 1, 1995·Current Opinion in Neurobiology·R J Keynes, G M Cook
Apr 1, 1993·The Journal of Comparative Neurology·P E PhelpsJ E Vaughn
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

❮ Previous
Next ❯

Citations

Jan 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M C HalloranJ Y Kuwada
Jul 20, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J JacobS Guthrie
May 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·W G Wadsworth, E M Hedgecock
May 13, 1996·Brain Research·W P NgA Lozano
Mar 13, 1998·Brain Research. Developmental Brain Research·B H Poe, J K Brunso-Bechtold
Nov 1, 1996·Trends in Neurosciences·A L Kolodkin
Feb 11, 2003·Progress in Neurobiology·Nobuhiko YamamotoFujio Murakami
Aug 1, 1996·Current Opinion in Genetics & Development·B K MüllerU Drescher
Feb 1, 1996·Current Opinion in Neurobiology·J G Culotti, A L Kolodkin
Jan 28, 2012·Nature Protocols·Liang Wang, Till Marquardt
Apr 2, 1999·The European Journal of Neuroscience·J Warrilow, S Guthrie
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·V Tzarfati-MajarA Klar
Apr 9, 2011·Journal of Neurotrauma·Harini G SundararaghavanDavid I Shreiber
Mar 20, 2010·Cold Spring Harbor Perspectives in Biology·Dario Bonanomi, Samuel L Pfaff
Jun 8, 2002·Annual Review of Neuroscience·Ryuichi Shirasaki, Samuel L Pfaff
Aug 11, 2000·Biological Chemistry·A B Huber, M E Schwab
Jun 18, 2005·Brain Research. Brain Research Reviews·María J BarallobreEduardo Soriano
Jan 24, 2003·The Journal of Comparative Neurology·Joseph-Pascal Mbiene, John David Roberts
Mar 16, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elvira T MambetisaevaVasi Sundaresan
Jan 12, 2011·The European Journal of Neuroscience·Kenta KobayashiKazuto Kobayashi
Mar 29, 2013·The European Journal of Neuroscience·Makio TorigoeFujio Murakami
Jun 22, 1999·Current Biology : CB·S Guthrie
Apr 10, 1999·Neuron·K T Nguyen Ba-CharvetA Chédotal
Apr 7, 1997·Biochemical and Biophysical Research Communications·G YamadaK Sugimura
Oct 20, 1995·Cell·R Keynes, G M Cook
May 19, 1995·Cell·J Dodd, A Schuchardt
Jul 17, 2016·Neuroscience·Ignacio Hernandez-MoratoMichael J Pitman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.