PMID: 3770053Aug 1, 1986Paper

Chemosensitivities of human clonogenic breast tumor cells

European Journal of Cancer & Clinical Oncology
V HugM Finders

Abstract

We developed an in vitro system for the testing of the inherent chemosensitivity of clonogenic tumor cells, and we applied the system to the evaluation of 104 human breast tumors. We observed the following: clonogenic breast tumor cells were more sensitive to 4-hydroperoxy-cyclophosphamide (a metabolite of cyclophosphamide with in vitro activity) than to 5-fluorouracil and to doxorubicin (the other two agents used in the frontline treatment of breast carcinoma). The sensitivity of these clonogenic breast tumor cells for mitoxantrone, bisantrene, 4'-epi-doxorubicin, and VP-16 was similar to that for doxorubicin and 5-fluorouracil, but it was less for cis-platinum. In vivo exposure to a combination of 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) did not change the sensitivity of cells towards 5-fluorouracil and doxorubicin, but lessened the sensitivity of some cells towards 4-hydroperoxycyclophosphamide. Furthermore, in vivo exposure to doxorubicin did not influence the sensitivity of cells towards the anthraquinone derivatives, 4'-epi-doxorubicin, mitoxantrone, and bisantrene. A comparison of the in vitro and in vivo chemosensitivity revealed that the assayed cell populations were biologically relevant: the concordanc...Continue Reading

References

Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson
Jan 1, 1984·International Anesthesiology Clinics·D A McClain, C C Hug
Jan 1, 1983·Investigational New Drugs·J G KuhnD D Von Hoff

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