Chemosensitization effects of simultaneous suppression of MDR1 and XIAP in multidrug resistant glioma cells.

Medical Oncology
Zhiqing ZhangSuping Wang

Abstract

We studied the mechanisms involved in the drug resistance of C6/ADR and compared the reversal effects of XIAP and MDR1 ASO used in combination and separately. Reverse transcription-PCR and Western blot were applied to detect the mRNA and protein levels, respectively. The results showed that XIAP and MDR1 ASO used separately could down-regulate the levels of XIAP and MDR1 in C6/ADR cells, respectively. XIAP and MDR1 ASO used in combination did not enhance the inhibition expression of XIAP and MDR1 of C6/ADR cells. The apoptosis of co-transfection group was significantly higher than XIAP ASO (P < 0.05). When used in combination the sensitivity of C6/ADR cells to ADR was increased significantly compared with XIAP or MDR1 ASO used separately (P < 0.05). The results indicated that both XIAP and MDR1 were involved in the drug resistance of C6/ADR cells. The sensitivity to ADR could be enhanced significantly when XIAP and MDR1 ASO used in combination.

References

Jul 17, 1997·Nature·Q L DeverauxJ C Reed
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Jan 15, 1999·Pathology Oncology Research : POR·G SzakácsB Sarkadi
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