PMID: 16535862Mar 16, 2006Paper

Chemosensitizers in drug transport mechanisms involved in protozoan resistance

Current Drug Targets. Infectious Disorders
Bruno PradinesJacques Barbe

Abstract

The emergence and spread of antiparasitic drug resistance pose a severe and increasing public health threat. Failures in prophylaxis or those in treatment with quinolines, hydroxynaphtoquinones, sesquiterpenic lactones, antifolate drugs, arsenic and antimony containing drugs sulfamides induce reemergence of parasitic-related morbidity and mortality. Resistance is often associated with alteration of drug accumulation into parasites, which results from a reduced uptake of the drug, an increased efflux or, a combination of the two processes. Resistance to quinolines, artemisinin derivatives and arsenicals and expression of an active efflux mechanism are more or less correlated in protozoa like Plasmodium spp., Leishmania spp., and Trypanosoma spp. Various parasite candidate genes have been proposed to be involved in drug resistance, each concerned in membrane transport. Genes encoding membrane glycoproteins, orthologue to the P-glycoproteins identified in MDR human cancer cells, have been described in these resistant pathogens in addition to various membrane proteins involved in drug transport. Several compounds have demonstrated, in the past decade, promising capability to reverse the drug resistance in parasite isolates in vitro...Continue Reading

Citations

Dec 30, 2006·Antimicrobial Agents and Chemotherapy·Iris L K WongLarry M C Chow
Jun 20, 2012·Antimicrobial Agents and Chemotherapy·Fabián E SáenzDennis E Kyle
Nov 6, 2008·Molecular and Biochemical Parasitology·Aline SchmidIsabelle Villena
Sep 3, 2010·Molecular Microbiology·Jigar J PatelMichael T Ferdig
Oct 5, 2006·Molecular and Biochemical Parasitology·Iris L K Wong, Larry M C Chow
Nov 3, 2007·Current Opinion in Infectious Diseases·Timothy J Egan, Catherine H Kaschula

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