Chemosensitizing multiple drug resistance of human carcinoma by Bicyclol involves attenuated p-glycoprotein, GST-P and Bcl-2

Cancer Biology & Therapy
Bing ZhuSamuel J Strada

Abstract

Bicyclol, a second generation of synthetic hepatoprotectant being used in China for anti-hepatitis therapy, shows chemosensitizing effect on reverting multiple drug resistance (MDR) of cytostatic agents in two established MDR carcinoma cell lines, vincristine resistant human stomatic epidermoid carcinoma VinRKB and adriamycin resistant human breast carcinoma AdrRMCF-7. The reversal rate of drug resistance was calculated from the changes of the IC50 of cell growth inhibition. Bicyclol at the concentration of 25, 50, 100 microM induced 2.8 7.3 and 20.7 fold, respectively, reversal of vincristine resistance in VinRKB cell. Bicyclol also reversed the cross-resistance of VinRKB cell to taxol and AdrRMCF-7 cell resistance to adriamycin at the similar range of potency. Further, Bicyclol recovered the reduced accumulation of adriamycin in AdrRMCF-7 cell partially to the level in drug-sensitive MCF-7 cell, indicate the inhibition of MDR related membrane efflux pump system. Overexpression of membrane p-glycoprotein coded by Mdr-1 genes, the most common efflux pump correlated to MDR, was found in both VinRKB and AdrRMCF-7 cells by Western blot and immunocytochemistry as compared with drug-sensitive cells. The p-glycoprotein was decreased ...Continue Reading

Citations

Mar 16, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yu-Ning SongYan-Na Cheng
Jan 22, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C-K WanD W F Fong
Sep 27, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li-rui SunXian-jun Qu
Dec 1, 2007·Integrative Cancer Therapies·Jianhua WangZengxia Hou
Aug 14, 2019·Journal of Cellular Biochemistry·Ying Zhou, Xiujuan Chai
Dec 29, 2019·Scientific Reports·Mohammad AzharuddinHirak K Patra

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