PMID: 6172791Jan 1, 1982Paper

Chemospecificity of ontogenetic units in the striatum: demonstration by combining [3H]thymidine neuronography and histochemical staining

Proceedings of the National Academy of Sciences of the United States of America
A M Graybiel, T L Hickey

Abstract

Neurons being generated in the striatum of 10 fetal cats were pulse labeled by injection of [3H]thymidine directly into the maternal uterus at times ranging between the 22nd and 30th days (E22-E30) of the 65-day gestational period. Many of the striatal neurons labeled during this interval were found, at adolescence, to form 100- to 600-mum-wide cell clusters in the caudate nucleus. In E24-E30 specimens, we compared the distributions of these cell clusters with the locations of patches of low acetylcholinesterase activity and high enkephalin immunoreactivity (the "striosomes') visualized in serially adjoining sections. We found precise matches between most of the cell clusters and the acetylcholinesterase-poor enkephalin-rich zones, regardless of the embryonic age at which exposure to the [3H]thymidine had occurred. We conclude that the histochemically distinct striosomal patch-works observed in the acetylcholinesterase and enkephalin preparations correspond to ontogenetic units of the striatum.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A M Graybiel, C W Ragsdale
Jan 2, 1979·Experimental Brain Research·A M GraybielS Moon Edley
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielC W Ragsdale
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M Graybiel, C W Ragsdale

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Citations

Jan 1, 1989·Brain Research. Developmental Brain Research·S R Vincent, K Semba
Feb 1, 1989·Developmental Biology·W J Wolfgang, M A Forte
Dec 31, 2002·Brain Research. Brain Research Reviews·Tadashi HamasakiYukitaka Ushio
Aug 26, 1998·Brain Research. Developmental Brain Research·E H van Vulpen, D van der Kooy
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wen-Lin LiaoFu-Chin Liu
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P G Layer, O Sporns
Aug 4, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joanna J Rowell, Clifton W Ragsdale
Aug 15, 2001·The Journal of Comparative Neurology·F ForutanC Andressen
Jan 1, 1995·Progress in Histochemistry and Cytochemistry·P G Layer, E Willbold
Jan 22, 2010·Journal of Neurochemistry·Emma Perez-CostasRosalinda C Roberts
Dec 19, 2014·The Journal of Comparative Neurology·Helen NewmanAnn M Graybiel
Feb 7, 2006·Brain Research·Anju VasudevanPradeep G Bhide
Oct 3, 1994·Brain Research·L S DureE D Bird
Mar 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·I Ruiz-DeDiegoR Moratalla
Apr 28, 2016·Scientific Reports·Daniel J LiputStephen R Ikeda
Jul 1, 1994·Journal of Child Neurology·A K Afifi
Jun 20, 2003·Journal of Neuroscience Research·Kaoru TakahashiHiroshi Takahashi
Sep 25, 2002·The Journal of Comparative Neurology·Rosalinda C Roberts, Joy K Knickman
Sep 2, 2017·FEBS Letters·Miguel Turrero García, Corey C Harwell
Jan 7, 1998·The Journal of Comparative Neurology·A F Sadikot, R Sasseville
Jul 9, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hsiao-Ying Kuo, Fu-Chin Liu
Jan 1, 1984·Experimental Brain Research·M D Crutcher, M R DeLong

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