PMID: 8938118Nov 1, 1996Paper

Chemosuppression of retinal axon growth by the mouse optic chiasm

Neuron
L C WangC Mason

Abstract

To determine whether diffusible guidance cues direct retinal axon growth and divergence at the optic chiasm, we cocultured mouse retinal and chiasm explants in collagen gels. The chiasm reduced retinal neurite lengths and numbers, but did not affect commissural or pontine neurite growth. This reduction in growth was equal for all retinal quadrants and occurred without reorienting the direction of neurite extension. The floor plate, another midline guidance locus, also suppressed retinal neurite outgrowth, whereas cortex or cerebellum explants did not. Growth suppression was not mediated by netrin-1, which instead enhanced retinal neurite extension. We propose that chemosuppression may be a general guidance mechanism that acts in intermediate targets to prime growth cones to perceive other, more specific cues.

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Citations

Feb 8, 2000·The Journal of Comparative Neurology·K Y ChungS O Chan
Mar 27, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Mann, C E Holt
Dec 22, 1999·Ophthalmology·D A ThompsonD S Taylor
Sep 15, 2001·Brain Research. Developmental Brain Research·K JohanssonB Ehinger
Feb 7, 1998·Current Opinion in Neurobiology·C A Mason, D W Sretavan
May 6, 1998·Current Opinion in Neurobiology·G CookR Keynes
May 6, 1998·Current Opinion in Neurobiology·E T Stoeckli, L T Landmesser
May 21, 1999·The European Journal of Neuroscience·B Llirbat, P Godement
May 14, 2010·Cold Spring Harbor Perspectives in Biology·Alain Chédotal, Linda J Richards
Jun 19, 2008·Annual Review of Neuroscience·Timothy J PetrosCarol A Mason
Jul 20, 2005·Progress in Retinal and Eye Research·Glen Jeffery, Lynda Erskine
Sep 16, 2003·Neuron·Scott E WilliamsMark Henkemeyer
Apr 10, 1999·Neuron·K T Nguyen Ba-CharvetA Chédotal
Jul 5, 2001·The Journal of Comparative Neurology·K Y ChungS O Chan
Dec 3, 2016·Developmental Neurobiology·Delphine S Prieur, Alexandra Rebsam
Oct 27, 2015·Neural Development·Paolo PanzaChristian Söllner
Apr 20, 2018·Proceedings. Biological Sciences·Pranesh Padmanabhan, Geoffrey J Goodhill
Dec 30, 2017·Journal of Molecular Neuroscience : MN·Ciqing YangJuntang Lin
Dec 22, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandra RafipayNeil Vargesson
Mar 1, 1997·Genes & Development·A Varela-Echavarría, S Guthrie

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