PMID: 9187966Apr 1, 1997Paper

Chemotactic factors released in culture by intact developing and healing skin lesions produced in rabbits by the irritant sulfur mustard

Inflammation
F TanakaD L Kreutzer

Abstract

Development, peak and healing lesions were induced in the skin of rabbits by topical applications (on different days) of the chemical irritant sulfur mustard (SM). Immediately after the rabbits were euthanized, the intact lesions were excised and organ-cultured for 17 to 20 hours. The culture fluids from early, peak and healing SM lesions all showed high chemotactic activity for both PMN and MN. This finding suggests that the PMN and MN, seen microscopically in tissue sections of the lesions, were entering continuously, even during the healing process. The chemotaxins identified were the eicosanoid LTB4, the chemokine IL-8, and proteases producing the complement fragment C5a. Other studies from our laboratory showed that the number of cells containing IL-1, IL-8, MCP-1, and GRO mRNAs was increased in SM lesions. Chemotactic activity was released by both live and dead (frozen and thawed) cell suspensions of PMN, MN, and fibroblasts, suggesting that these cells were major sources of the chemotaxins produced by the SM lesion explants. Explants of normal skin produced considerable chemotactic activity for MN, but not for PMN. Chemotactic activity for PMN, and the release of LTB4, IL-8 and proteases cleaving C5 to C5a, occurred only...Continue Reading

Citations

Nov 18, 2000·Journal of Biochemical and Molecular Toxicology·C L SabourinR P Casillas
Jan 5, 2002·International Journal of Toxicology·C M ArroyoB E Hackley
Oct 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael P ShakarjianJeffrey D Laskin
Apr 18, 2013·Cutaneous and Ocular Toxicology·Hassan GhasemiTooba Ghazanfari
Dec 21, 2004·Journal of Korean Medical Science·Hyo Seok ChungYoung Hwan Lee
Aug 10, 1999·Burns : Journal of the International Society for Burn Injuries·D E FaunceE J Kovacs
May 22, 2003·International Immunopharmacology·Jonathan M LevittJohn F Sweeney
Mar 24, 2004·International Immunopharmacology·Ashley K VavraJonathan M Levitt

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