Chemotaxis, chemokine receptors and human disease.

Cytokine
Tian JinDale Hereld

Abstract

Cell migration is involved in diverse physiological processes including embryogenesis, immunity, and diseases such as cancer and chronic inflammatory disease. The movement of many cell types is directed by extracellular gradients of diffusible chemicals. This phenomenon, referred to as "chemotaxis", was first described in 1888 by Leber who observed the movement of leukocytes toward sites of inflammation. We now know that a large family of small proteins, chemokines, serves as the extracellular signals and a family of G-protein-coupled receptors (GPCRs), chemokine receptors, detects gradients of chemokines and guides cell movement in vivo. Currently, we still know little about the molecular machineries that control chemokine gradient sensing and migration of immune cells. Fortunately, the molecular mechanisms that control these fundamental aspects of chemotaxis appear to be evolutionarily conserved, and studies in lower eukaryotic model systems have allowed us to form concepts, uncover molecular components, develop new techniques, and test models of chemotaxis. These studies have helped our current understanding of this complicated cell behavior. In this review, we wish to mention landmark discoveries in the chemotaxis research ...Continue Reading

References

Jan 1, 1988·Annual Review of Cell Biology·P N Devreotes, S H Zigmond
Dec 16, 1987·Biochemical and Biophysical Research Communications·A WalzM Baggiolini
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T YoshimuraE J Leonard
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·T M KonijnD S Barkley
Jan 1, 1982·Annual Review of Physiology·G Gerisch
Jul 7, 1997·The Journal of Experimental Medicine·M NietoF Sánchez-Madrid
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer
Apr 30, 1999·Science·C A Parent, P N Devreotes
Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K E BalashovW W Hancock
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·T D PollardR D Mullins
Dec 21, 2000·The Journal of Cell Biology·J M HaughT Meyer
Sep 12, 2001·Trends in Biochemical Sciences·C Y ChungR A Firtel
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·I V Maly, G G Borisy
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Marina SaettaLeonardo M Fabbri
Jun 14, 2002·Cell·Frank I Comer, Carole A Parent
Jun 14, 2002·Cell·Miho Iijima, Peter Devreotes
Jul 19, 2002·Current Biology : CB·Orion D Weiner
Sep 6, 2002·Nature·Henry R Bourne, Orion Weiner
Nov 1, 2002·Developmental Cell·Miho IijimaPeter Devreotes
Jan 16, 2003·Immunology Letters·Bernhard Moser, Lisa Ebert
Feb 26, 2003·Cell·Thomas D Pollard, Gary G Borisy
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Marina SaettaRenzo Zuin
Jun 9, 2004·Trends in Cell Biology·Theresia E B StradalGiorgio Scita

❮ Previous
Next ❯

Citations

Apr 9, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Yantang WangGuixiu Shi
Nov 26, 2010·Molecules and Cells·Injun ChaTaeck J Jeon
Apr 24, 2009·Molecular and Cellular Biochemistry·Sarah J Annesley, Paul R Fisher
Apr 3, 2013·Bulletin of Mathematical Biology·O StancevicB I Henry
Aug 28, 2012·The Journal of Microbiology·Mi-Rae Lee, Taeck J Jeon
Aug 27, 2013·Acta Pharmacologica Sinica·Stavros Apostolakis, Demetrios Spandidos
Dec 22, 2011·Nature Communications·Eduard StefanStephen W Michnick
Sep 3, 2011·Southern Medical Journal·Hamid AbousaidiGholamhossein Hassanshahi
May 11, 2011·Future Medicinal Chemistry·Christofer S Tautermann
Jun 27, 2014·PLoS Computational Biology·Christian DienerEdda Klipp
May 22, 2013·Mediators of Inflammation·Jyoti PatelEileen McNeill
May 23, 2014·Cellular and Molecular Life Sciences : CMLS·Yulia ArtemenkoPeter N Devreotes
Jul 25, 2012·Cellular and Molecular Life Sciences : CMLS·Akiko MukaiSatoshi Goto
Sep 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Monica SkogeWouter-Jan Rappel
Feb 26, 2016·International Immunopharmacology·Keqiang ChenShaobo Su
Aug 9, 2011·Seminars in Cell & Developmental Biology·Huaqing Cai, Peter N Devreotes
Jun 15, 2011·Trends in Cell Biology·Jing Li, Francis Lin
May 10, 2011·Revue des maladies respiratoires·N RocheM Aubier
Feb 25, 2009·Bioorganic & Medicinal Chemistry Letters·Shankaran KothandaramanLihu Yang
Mar 8, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Tian Jin
Aug 19, 2010·The EMBO Journal·Anastacia Berzat, Alan Hall
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tomonori AoyamaEkihiro Seki
Oct 31, 2009·Acta Tropica·Vanessa Amaral MendonçaAntonio Lúcio Teixeira
Dec 7, 2014·Chinese Journal of Natural Medicines·Sen-Sen LinSheng-Tao Yuan
Jul 21, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nada AlaaeddineJohn A Di Battista
Jul 25, 2013·Current Opinion in Cell Biology·Tian Jin

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