PMID: 9440510Jan 24, 1998Paper

Chemotaxis in Borrelia burgdorferi

Journal of Bacteriology
W ShiM A Lovett

Abstract

Borrelia burgdorferi is a motile spirochete which has been identified as the causative microorganism in Lyme disease. The physiological functions which govern the motility of this organism have not been elucidated. In this study, we found that motility of B. burgdorferi required an environment similar to interstitial fluid (e.g., pH 7.6 and 0.15 M NaCl). Several methods were used to detect and measure chemotaxis of B. burgdorferi. A number of chemical compounds and mixtures were surveyed for the ability to induce positive and negative chemotaxis of B. burgdorferi. Rabbit serum was found to be an attractant for B. burgdorferi, while ethanol and butanol were found to be repellents. Unlike some free-living spirochetes (e.g., Spirochaeta aurantia), B. burgdorferi did not exhibit any observable chemotaxis to common sugars or amino acids. A method was developed to produce spirochete cells with a self-entangled end. These cells enabled us to study the rotation of a single flagellar bundle in response to chemoattractants or repellents. The study shows that the frequency and duration for pausing of flagella are important for chemotaxis of B. burgdorferi.

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Citations

Oct 11, 2001·Microbiology and Immunology·T UmemotoT Ogawa
Jun 2, 2004·Journal of Molecular Microbiology and Biotechnology·Ronald J Limberger
Jun 9, 2009·Vector Borne and Zoonotic Diseases·Siddharth Y Srivastava, Aravinda M de Silva
Nov 19, 2009·The Journal of Clinical Investigation·Star M Dunham-EmsJustin D Radolf
Apr 9, 2020·Biomolecules·Shuichi Nakamura
May 11, 2002·Journal of Bacteriology·Renate LuxWenyuan Shi
Nov 18, 2005·Journal of Bacteriology·M A MotalebNyles W Charon
Sep 25, 2012·Applied and Environmental Microbiology·Ambroise LambertMathieu Picardeau
Nov 14, 2002·Annual Review of Genetics·Nyles W Charon, Stuart F Goldstein
Sep 13, 2008·The FEBS Journal·Nadeem O KaakoushGeorge L Mendz
Dec 16, 2016·Nature Reviews. Disease Primers·Allen C SteerePaul S Mead
Nov 22, 2017·Infection and Immunity·Michael W CurtisJenifer Coburn
Sep 1, 2019·Applied and Environmental Microbiology·Xiangsheng ZhangRebecca E Parales
Aug 5, 2020·FEBS Letters·Vinaya DulipatiJaana Panelius
Nov 30, 2021·Journal of Bacteriology·Emily N KennedyRobert B Bourret

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