PMID: 6980007Jun 1, 1982Paper

Chemotaxis in yersinia arthritis. In vitro stimulation of neutrophil migration by HLA--B27 positive and negative sera

Arthritis and Rheumatism
H RepoO Laitinen

Abstract

Chemotactic and chemokinetic migration of polymorphonuclear leukocytes in sera from patients with previous yersinia arthritis and from healthy subjects with or without HLA--B27 were studied by the leading front method. Irrespective of yersinia arthritis, zymosan-activated sera from subjects who were HLA--B27 positive were significantly more chemokinetic than were HLA--B27 negative zymosan-activated sera from healthy control subjects. The chemotactic activities of zymosan-activated sera that were HLA--B27 positive or negative, as determined by chemotactic increments, were much the same. The results suggest that zymosan-activated serum that is HLA--B27 positive stimulates random migration of polymorphonuclear leukocytes, but not their directional migration, more than does HLA--B27 negative serum that has been zymosan activated. This may contribute to accumulation of polymorphonuclear leukocytes at the site of inflammation in vivo and thereby to inflammatory symptoms in yersinia arthritis patients with HLA--B27.

References

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Jan 1, 1979·Current Topics in Pathology. Ergebnisse Der Pathologie·P C Wilkinson, J M Lackie
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Citations

Dec 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·H RepoO Laitinen
Feb 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·H Repo, M Leirisalo-Repo
Mar 16, 2012·Immunology and Cell Biology·Shimon SakaguchiRanjeny Thomas
Jan 1, 1988·Scandinavian Journal of Rheumatology·E Kåss
Feb 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Ristola
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·M Leirisalo-Repo, H Repo
Jan 1, 1990·Scandinavian Journal of Rheumatology. Supplement·M Leirisalo-Repo
Apr 1, 1984·Annals of the Rheumatic Diseases·C T PeaseH L Currey
Jun 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·S L MarklundS Koskimies
Nov 1, 1985·Seminars in Arthritis and Rheumatism·L E McGuiganJ P Edmonds
Aug 1, 1989·Baillière's Clinical Rheumatology·K Aho

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