Chemotaxis-Instructed Intracellular Staphylococcus aureus Infection Detection by a Targeting and Self-Assembly Signal-Enhanced Photoacoustic Probe

Nano Letters
Qian CaiHao Wang

Abstract

Intracellular invasion and the survival of Staphylococcus aureus in phagocytic cells has been regarded as one of the mechanisms that leads to the treatment failure of S. aureus infection and potential antibiotic resistance. The detection of infected phagocytic cells plays an important role in guiding antibiotic treatment and in reducing drug resistance. The development of a sensitive and specific imaging probe to visualize the intracellular bacteria is quite challenging. In this work, we report a photoacoustic agent (MPC) that is able to detect intracellular S. aureus infection through a dynamic process, including (i) active targeting and internalization into macrophage cells, (ii) specific molecular tailoring by caspase-1 in infected macrophage cells, and (iii) enhancement of the photoacoustic (PA) signal owing to molecular self-assembly. The PA signal per area of the "stimuli-induced assembly" agent (MPC) increases more than 2-fold over that of the active targeting control agent (MPSC). Finally, based on this approach, the average PA signal in the infected site is enhanced by approximately 2.6-fold over that of the control site. We envision that this PA contrast agent may provide a new approach for the selective and sensitive...Continue Reading

References

Mar 28, 2001·Science·J M Lehn, A V Eliseev
Sep 23, 2006·Cell·Maya Saleh
Dec 21, 2006·Journal of the American Chemical Society·W Matthew LeevyBradley D Smith
Feb 26, 2011·Expert Opinion on Drug Delivery·Elena V BatrakovaAlexander V Kabanov
Sep 11, 2012·Advanced Materials·Meng-Hua XiongJun Wang
Apr 17, 2014·Advanced Materials·Huanxiang YuanShu Wang
Sep 18, 2014·Nature Communications·Neelkanth M BardhanAngela M Belcher
Dec 20, 2014·Science·Woon Ju Song, F Akif Tezcan
Feb 18, 2015·Chemical Society Reviews·Jing LiangBin Liu
Nov 5, 2015·Nature·Sophie M LeharSanjeev Mariathasan
Aug 9, 2016·Chemical Reviews·Masahiko Taniguchi, Jonathan S Lindsey
Nov 1, 2016·Nature Nanotechnology·Charalampos G PappasRein V Ulijn
Jun 20, 2017·Nature Reviews. Microbiology·Erin E McClureJoao H F Pedra
Aug 25, 2017·Nature Chemistry·Jan StöhrWilliam F DeGrado
Dec 26, 2017·Angewandte Chemie·Jie ZhanZhimou Yang
Feb 15, 2018·ACS Applied Materials & Interfaces·Qian CaiHao Wang
Jun 30, 2018·Nature Biomedical Engineering·Sazid HussainErkki Ruoslahti

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Citations

Sep 10, 2020·Advanced Healthcare Materials·Yu DengGaolin Liang
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paolo DogniniFrancesca Giuntini
Oct 30, 2019·Journal of the American Chemical Society·Effie Y ZhouJefferson Chan
Feb 8, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Jin ZhouHao Wang
Sep 9, 2021·Nanoscale·Qiaochu JiangXianbao Sun
Jan 14, 2022·Nano Convergence·Nam Hyeong KimYong Ho Kim

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