Chemotaxis of the peritoneal cells and the detection of a chemo-attractant in the effluent from peritoneal dialysis patients

European Journal of Clinical Investigation
H J BosR H Beelen

Abstract

The migration of peritoneal cells from 25 continuous ambulatory peritoneal dialysis patients and eight healthy women undergoing laparoscopy were studied. Peritoneal cells of continuous ambulatory peritoneal dialysis patients migrated to commonly used chemoattractants, like N-formyl-methionyl-leucyl-phenyl-alanine-methyl- ester and casein, but they also migrated to high concentrations of recombinant interleukin-1 alpha and to endotoxin (lipopolysaccharide). In the peritoneal effluent from continuous ambulatory peritoneal dialysis patients a rather heat stable chemoattractant was found with a molecular weight of 40-200 kDa with an optimal activity at approximately 125 kDa. The chemoattractant is a protein and is not complement factor 5a or interleukin-1 and was only found in peritoneal effluent from continuous ambulatory peritoneal dialysis patients, but not in peritoneal fluid from healthy women undergoing laparoscopy. Therefore, peritoneal dialysis might induce the generation of a chemoattractant. The optimal chemotactic response of peritoneal cells from continuous ambulatory peritoneal dialysis patients to N-formyl-methionyl-leucyl-phenyl-alanine-methyl- ester in medium could be enhanced by replacing the medium by peritoneal e...Continue Reading

References

Dec 1, 1978·The Journal of Experimental Medicine·R M FranklinA M Silverstein
Jan 1, 1979·Advances in Immunology·D C Morrison, J L Ryan
Jul 1, 1989·Kidney International·H J BosR H Beelen
Jul 1, 1972·The Journal of Experimental Medicine·I GeryB H Waksman
Apr 1, 1968·The Journal of Experimental Medicine·P A Ward, E L Becker
Apr 1, 1983·Journal of Cellular Physiology·S E Yen, W S Walker
Sep 1, 1984·Kidney International·J T Dulaney, F E Hatch
Jan 1, 1984·Annual Review of Immunology·K A JoinerM M Frank
Nov 1, 1984·Kidney International·C S GoldsteinS D Douglas
Oct 1, 1983·Archives of Internal Medicine·A Spital, J D Scandling
Jan 1, 1984·American Journal of Obstetrics and Gynecology·J HalmeR Wing
Aug 2, 1984·The New England Journal of Medicine·Y Matzner, A Brzezinski
Jan 1, 1980·Journal of Immunological Methods·W FalkE J Leonard
Apr 1, 1982·American Journal of Obstetrics and Gynecology·J HalmeS Raj
Jun 1, 1981·Fertility and Sterility·A F HaneyJ B Weinberg

❮ Previous
Next ❯

Citations

Sep 14, 1994·Journal of Immunological Methods·M G BetjesR H Beelen
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H NorimatsuJ Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M R Pourshafie, G Sonnenfeld
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M R Hespanhol, B Mantovani
© 2021 Meta ULC. All rights reserved