Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sandra MacfarlaneG T Macfarlane

Abstract

The etiology of ulcerative colitis (UC) is unknown, but evidence links it to bacteria belonging to the normal colonic microbiota. The aims of this study were to characterize bacteria colonizing the rectal epithelium, and to investigate whether significant differences existed in UC. Rectal biopsy specimens were obtained via endoscopy from 9 patients with active colitis and 10 patients without inflammatory bowel disease. Complex bacterial communities colonized the rectal mucosa in all subjects. Overall, 72 bacterial taxa (18 genera) were detected. Twenty species were common to both groups, but only differences in bifidobacteria were statistically significant (P=.005). Peptostreptococci were only detected in patients with UC. Microscopy showed that bacteria in mucosal biofilms often occurred in microcolonies. Interindividual variations in mucosal biofilms made it difficult to assign a role for specific bacteria in UC etiology. However, differences in bifidobacteria and peptostreptococci may implicate these organisms in this disease.

References

Jan 1, 1979·Infection and Immunity·C L HartleyM H Richmond
Jan 1, 1979·The American Journal of Clinical Nutrition·A B Onderdonk, J G Bartlett
Jul 9, 1988·BMJ : British Medical Journal·D A Burke, A T Axon
Jun 1, 1986·Journal of General Microbiology·G T MacfarlaneC Allison
Sep 1, 1983·Scandinavian Journal of Gastroenterology·M TvedeS N Rasmussen
Mar 1, 1983·Applied and Environmental Microbiology·S C CroucherR J Turner
May 1, 1994·Gut·J G Ruseler-van EmbdenL M van Lieshout
Jan 1, 1997·Journal of Medical Microbiology·I R PoxtonA Ferguson
Jun 8, 2001·The American Journal of Clinical Nutrition·L Lu, W A Walker
Sep 5, 2002·Acta Oto-laryngologica. Supplementum·Nicola QuarantaAntonio Quaranta
Apr 5, 2003·Applied and Environmental Microbiology·Mark J Hopkins, George T Macfarlane

❮ Previous
Next ❯

Citations

Nov 21, 2007·The British Journal of Nutrition·Francisco Guarner
Jul 17, 2009·The British Journal of Nutrition·P C CalderJ Zhao
Oct 6, 2010·The British Journal of Nutrition·Marcel RoberfroidAgnes Meheust
Sep 18, 2009·The Journal of Biological Chemistry·Donald A MacKenzieNathalie Juge
May 10, 2005·The British Journal of Nutrition·S MacfarlaneG T Macfarlane
Nov 30, 2005·The Proceedings of the Nutrition Society·Elizabeth Furrie
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra MacfarlaneJohn F Dillon
Feb 7, 2013·Inflammatory Bowel Diseases·Mirjana Rajilić-StojanovićWillem M de Vos
Feb 3, 2012·Biological Reviews of the Cambridge Philosophical Society·Annemarie Boleij, Harold Tjalsma
Sep 8, 2006·Applied and Environmental Microbiology·Sandra Macfarlane, George T Macfarlane
Sep 25, 2007·Applied and Environmental Microbiology·Shakil AhmedSandra Macfarlane
Nov 5, 2005·Applied and Environmental Microbiology·Sandra MacfarlaneGeorge T Macfarlane
May 24, 2012·MBio·Thierry PédronPhilippe J Sansonetti
Jan 26, 2011·MBio·Raina N FichorovaUNKNOWN Extremely Low Gestation Age Newborns (ELGAN) Study Investigators
Dec 5, 2008·Microbiology and Molecular Biology Reviews : MMBR·Sarah LebeerSigrid C J De Keersmaecker
Oct 28, 2006·Postgraduate Medical Journal·Milan LukasZdenek Maratka
Feb 26, 2011·World Journal of Gastroenterology : WJG·Francesca Fava, Silvio Danese
Oct 29, 2010·Gut and Liver·Melissa FriswellJonathan Rhodes
Nov 13, 2014·The Journal of Nutrition, Health & Aging·B LakshminarayananR P Ross
Feb 4, 2016·Gastroenterology Research and Practice·Ping YaoYongbo Cheng
Nov 19, 2015·Journal of Clinical Pathology·Alessandro Di CerboTommaso Iannitti
Jan 25, 2008·Journal of Applied Microbiology·G T MacfarlaneS Macfarlane
Jan 23, 2009·The British Journal of Surgery·F E RowanP R O'Connell
Apr 24, 2007·Journal of Applied Microbiology·S Macfarlane, J F Dillon
Apr 3, 2008·Molecular Nutrition & Food Research·Helen SteedSandra Macfarlane
Aug 22, 2006·Alimentary Pharmacology & Therapeutics·S MacfarlaneJ H Cummings
Aug 10, 2007·Environmental Microbiology·Mirjana Rajilić-StojanovićWillem M de Vos
Mar 16, 2012·Journal of Food Science·Vikas SangwanBabar Ali
Jan 3, 2013·Phytotherapy Research : PTR·F Di BartolomeoW Van den Ende
Jan 6, 2011·Letters in Applied Microbiology·S LebeerS C J De Keersmaecker
Nov 13, 2010·Journal of Applied Microbiology·B BahramiG T Macfarlane
Oct 13, 2006·Seminars in Immunology·Gerald W Tannock
Nov 23, 2010·Journal of Medical Microbiology·Aileen Robertson SmithGeorge Tennant Macfarlane
Feb 14, 2008·Expert Opinion on Therapeutic Targets·Keiichi Mitsuyama, Michio Sata
May 28, 2014·FEMS Microbiology Reviews·Mirjana Rajilić-Stojanović, Willem M de Vos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.