Chemotherapeutic approaches for targeting cell death pathways.

The Oncologist
M Stacey Ricci, Wei-Xing Zong

Abstract

For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death in mammalian tissues. It also has been increasingly noted that conventional chemotherapeutic agents not only elicit apoptosis but other forms of nonapoptotic death such as necrosis, autophagy, mitotic catastrophe, and senescence. This review presents background on the signaling pathways involved in the different cell death outcomes. A re-examination of what we know about chemotherapy-induced death is vitally important in light of new understanding of nonapoptotic cell death signaling pathways. If we can precisely activate or inhibit molecules that mediate the diversity of cell death outcomes, perhaps we can succeed in more effective and less toxic chemotherapeutic regimens.

References

Jul 1, 1979·Archives of Biochemistry and Biophysics·R A Haworth, D R Hunter
Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Aug 9, 1991·Cell·R Li, A W Murray
Sep 1, 1991·Experimental Cell Research·J W ShayW E Wright
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D LienardF J Lejeune
Sep 1, 1971·The Journal of Pathology·J F Kerr
Jun 1, 1984·Archives of Biochemistry and Biophysics·K L OlgiatiW A Toscano
Feb 2, 1995·Nature·J DheinP H Krammer
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Aug 26, 1993·Nature·J OgasawaraS Nagata
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B Grasl-KrauppR Schulte-Hermann
Feb 7, 1997·Cell·S Nagata
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J M de MurciaG de Murcia
Oct 6, 1997·Genes & Development·Z Q WangE F Wagner
May 2, 1998·The EMBO Journal·C ScaffidiM E Peter
Apr 29, 1998·The Journal of Biological Chemistry·J G PastorinoJ L Farber
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaritaY Tsujimoto
Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Nov 5, 1999·Advances in Cancer Research·P Hainaut, M Hollstein
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·H C Ha, S H Snyder
Jan 5, 2000·Science·B A FosterF Rastinejad
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A M ChinnaiyanA Rehemtulla
Feb 22, 2000·The Journal of Biological Chemistry·P R GravesH Piwnica-Worms
Feb 26, 2000·Carcinogenesis·L J Marnett
Mar 30, 2000·Journal of Photochemistry and Photobiology. B, Biology·P UehlingerN Lange

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Citations

Aug 25, 2009·European Journal of Nutrition·Daniel Alejandro Barrio, María Cristina Añón
Jul 28, 2009·Apoptosis : an International Journal on Programmed Cell Death·Angeliki KoryllouVassiliki Pletsa
Feb 13, 2008·Cell Biology and Toxicology·Jose A Aquino EsperanzaNora Cristina Brandan
Aug 15, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmet BiliciMahmut Gumus
Aug 1, 2013·Biochemical and Biophysical Research Communications·Keiko Morotomi-YanoKen-ichi Yano
Jun 28, 2011·Biochemical Pharmacology·Annick NotteCarine Michiels
Mar 14, 2009·Parasitology·R F S Menna-BarretoS L De Castro
Nov 23, 2011·Biochemistry·Russell J ErnstJacqueline K Barton
Dec 20, 2008·Cell Death and Differentiation·G-H HaC-W Lee
Jun 21, 2008·Cell Death and Differentiation·E M YazlovitskayaD E Hallahan
Jun 30, 2009·The Journal of Biological Chemistry·Saverio TarditoRenata Franchi-Gazzola
Jun 30, 2009·Photomedicine and Laser Surgery·Tina L KresfelderHeidi Abrahamse
Jun 7, 2011·Pharmacogenetics and Genomics·Yujia WenMary Eileen Dolan
Feb 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Vladimir BeljanskiCharles D Smith
Oct 11, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·You-Cheng HseuHsin-Ling Yang
Mar 11, 2009·Journal of Biomedical Science·Huan-Yao Lei, Chih-Peng Chang
Dec 25, 2013·PloS One·Lidija K GorsicM Eileen Dolan
Jan 15, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Letícia da Conceição BragaAgnaldo Lopes da Silva Filho
May 9, 2012·Chemotherapy Research and Practice·Fawzi Aoudjit, Kristiina Vuori
Apr 10, 2014·Apoptosis : an International Journal on Programmed Cell Death·Bettina M KaminskiSandra Ulrich-Rückert
Jun 4, 2014·Archives of Biochemistry and Biophysics·Keiko Morotomi-YanoKen-ichi Yano
Dec 3, 2014·Biochemical and Biophysical Research Communications·Zhi XieYa-fang Shen
Jul 19, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lamine BournineAkeila Bellahcène
Mar 15, 2013·Metallomics : Integrated Biometal Science·Kogularamanan SuntharalingamRamon Vilar
Nov 12, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fuhao ChuHaimin Lei
Aug 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadiah AbuNoorjahan Banu Alitheen
Jul 23, 2013·Mutation Research·Diana L BordinJoão A P Henriques
May 21, 2013·Acta histochemica·Dariusz GrzankaMagdalena Izdebska
May 1, 2012·Cancer Letters·Chandramu ChettySajani S Lakka
May 5, 2012·Gynecologic Oncology·Letícia da Conceição BragaAgnaldo Lopes da Silva-Filho

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