Chemotherapeutic efficacy of E-5-(2-bromovinyl)-2'deoxyuridine for orofacial infection with herpes simplex virus type 1 in mice

The Journal of Infectious Diseases
N H ParkE De Clercq

Abstract

Systemic or topical treatment with E-5-(2-bromovinyl)2'-deoxyuridine (BVDU) showed significant efficacy against orofacial infection with herpes simplex virus type 1 (HSV-1) in hairless mice. The chemotherapeutic response to BVDU was dose-dependent and clearly evident even when the treatment was initiated during the clinical manifestation of HSV-1 infection at 72 hr after inoculation. Early initiation of therapy with BVDU at 3 or 24 hr after inoculation significantly prevented the establishment of latent HSV infection in the trigeminal ganglia of mice, but systemic treatment with BVDU did not influence already established latent HSV-1. The chemotherapeutic efficacy of BVDU was comparable to that of acyclovir in the present animal model.

Citations

Jan 1, 1984·Pharmacology & Therapeutics·E De Clercq, R T Walker
Jan 1, 1989·Pharmacology & Therapeutics·M L LandryG D Hsiung
Apr 1, 1984·European Journal of Cancer & Clinical Oncology·J Wildiers, E De Clercq
Apr 1, 1984·European Journal of Clinical Microbiology·E de Clercq
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C AmeyeE de Clercq

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