Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas.

Journal of Neurosurgery
T HoshinoM Barker

Abstract

Four patients received 3H-thymidine 4 to 7 days and vinblastine 4 to 6 hours prior to operation for recurrent malignant gliomas (three glioblastomas and one anaplastic astrocytoma). Tumor biopsies obtained at operation were fixed for routine histological studies and radioautography. The tumors' growth fractions averaged 0.28 with a range of 0.14 to 0.39. The tumor cell cycle time calculated in three patients had a mean duration of 57 hours with a standard deviation of 6 hours. The authors concluded that: 1) single short-term courses of cell-cycle specific chemotherapeutic agents alone will probably fail to achieve either significant reduction in tumor mass or dramatic clinical improvement; 2) cell-cycle phase-specific drugs should be administered to maintain effective blood levels over 2 to 3 days for maximal tumor cell kill. Tumor growth rate appears to correlate with the fraction of proliferating cells rather than the length of the tumor cell cycle. The scientific basis for combination drug and multimodality therapy is discussed.

References

Jan 1, 1969·Brain : a Journal of Neurology·J S ChopraD A Montgomery
Nov 1, 1967·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M F Rajewsky
Jul 1, 1972·Journal of Neurosurgery·T HoshinoD Fewer
Jun 1, 1974·Journal of the National Cancer Institute·A R KumarC B Wilson
Nov 1, 1971·Cancer·J J TerzW Lawrence
Jun 1, 1970·The Journal of Clinical Investigation·S ShirakawaE Frei
Jan 1, 1966·Diseases of the Colon and Rectum·C M Earley, A J Martens
Oct 1, 1966·Journal of Chronic Diseases·M V Barrow
Nov 1, 1967·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O H Iversen
Jun 1, 1959·Experimental Cell Research·H QUASTLER, F G SHERMAN
May 1, 1964·Canadian Journal of Physiology and Pharmacology·C T BEERJ BELL
Apr 1, 1940·Journal of Neurology and Psychiatry·H J Scherer

❮ Previous
Next ❯

Citations

Jul 14, 2000·The Journal of Gene Medicine·M AghiX O Breakefield
Jan 1, 1987·Acta Neuropathologica·F GiangasperoH Stein
Jan 1, 1978·Acta neurochirurgica·K Jellinger
Jan 1, 1996·Acta neurochirurgica·L U WahlbergJ Boëthius
Jan 1, 1984·Neurosurgical Review·Y UshioN Arita
Sep 1, 1988·Journal of Neuro-oncology·Y YoshiiK Sugiyama
Jun 17, 1976·The New England Journal of Medicine·R UrtasunC Fryer
Apr 2, 2004·American Journal of Clinical Oncology·Branislav JeremicNebojsa Nikolic
Feb 1, 1977·Journal of Neurosurgery·M K RosenblumC B Wilson
Jul 1, 1978·Journal of Neurosurgery·T HoshinoJ W Gray
Apr 1, 1986·Journal of Neurosurgery·T NagashimaS J DeArmond
Dec 1, 1986·Journal of Neurosurgery·J W BookwalterM Kristofik
Feb 1, 1987·Journal of Neurosurgery·D W KimmelW R Shapiro
Jan 1, 1979·Pharmacology & Therapeutics·F A Valeriote
Feb 1, 1977·Journal of Neurosurgery·C H Tator, W Wassenaar
Jan 5, 2002·Expert Opinion on Investigational Drugs·S I Rapoport
Nov 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W D HeissB Mamoli
Sep 13, 2015·Mathematical Medicine and Biology : a Journal of the IMA·Christian EngwerChristina Surulescu
Jan 1, 1990·British Journal of Neurosurgery·H B MishraT Joseph
Jan 1, 1987·Ultrastructural Pathology·B W Scheithauer, J M Bruner
Aug 1, 1988·Cancer·K G ChoY Shimosato
Jun 1, 1978·Cancer·M L RosenblumC B Wilson
Sep 1, 1979·Cancer·T Hoshino, C B Wilson
Jun 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·V A LevinH D Landahl

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.