Chemotherapeutic Potential of Carthamus Oxycantha Root Extract as Antidiarrheal and In Vitro Antibacterial Activities

Antibiotics
Muhammad IkramGaber El-Saber Batiha

Abstract

Our research work was designed to investigate the curative and preventive effects of Carthamus oxycantha root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, and Salmonella typhi, while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400 mg/kg (body weight, b.w) orally. The methanol extract of C. oxycantha significantly (p < 0.001) decreased the frequency of defecation, and wet stools in a dose depended on the manner of after receiving magnesium sulfate (2 g/kg (b.w)) and castor oil (1.0 mL/mice). Furthermore, the extract of C. oxycantha showed concentration-dependent antimicrobial properties against S. aureus followed by S. typhi, E. coli, and P. aeroginosa bacterial strains, with inhibitions ranging from 10.5-15 mm. These findings show significant results that C. oxycantha is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action.

References

Feb 1, 1977·Prostaglandins·S M Karim, P G Adaikan
Feb 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·T G ClearyL K Pickering
Jul 11, 2000·Journal of Agricultural and Food Chemistry·H Zieliński, H Kozłowska
Mar 29, 2001·Journal of Ethnopharmacology·D SrinivasanP Lakshmana Perumalsamy
Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·J M Andrews
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Cristina PavetoHéctor N Torres
Jul 6, 2004·Journal of Ethnopharmacology·Xiang Lan PiaoJeong Hill Park
Dec 22, 2007·Journal for Specialists in Pediatric Nursing : JSPN·Roxie L Foster
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Ramzi A A MothanaUlrike Lindequist
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martina JonssonKimmo Peltonen
Jan 29, 2013·BMC Complementary and Alternative Medicine·Shemsu UmerNigatu Kebede
Dec 18, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shijun YueJin-Ao Duan
Aug 16, 2014·Journal of Advanced Pharmaceutical Technology & Research·Mohanjit KaurBimlesh Kumar
Aug 7, 2016·BMC Complementary and Alternative Medicine·Eshetie Melese BirruAsegedech Tsegaw
Aug 24, 2016·BMC Complementary and Alternative Medicine·Teshager YacobTeshome Nedi
Feb 3, 2017·The Pediatric Infectious Disease Journal·Chih-Hsien ChuangCheng-Hsun Chiu
Dec 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hu ChenNingjia He
May 28, 2019·PLoS Neglected Tropical Diseases·Gaber El-Saber BatihaIkuo Igarashi
Feb 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaber El-Saber BatihaIkuo Igarashi
Feb 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaber El-Saber BatihaIkuo Igarashi

Citations

Aug 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hefa Mangzira KemungBey-Hing Goh
Jul 28, 2020·International Journal of Molecular Sciences·Gaber El-Saber BatihaHelal F Hetta

Methods Mentioned

BETA
sedation

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