PMID: 6406513Jan 1, 1983Paper

Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combinations

Journal of Cancer Research and Clinical Oncology
G EichlerD Schmähl

Abstract

The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.

References

Mar 1, 1977·Journal of the National Cancer Institute·S K Carter, R L Comis
Nov 1, 1974·Cancer·R L Comis, S K Carter
Jan 1, 1982·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·D L Kisner, J S Macdonald
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·M HabsD Schmähl
Dec 5, 1958·Annals of the New York Academy of Sciences·N MANTEL
Jul 28, 1962·JAMA : the Journal of the American Medical Association·F J ANSFIELDA R CURRERI

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