Chemotherapy affects the pattern of failure after shear loading of the proximal tibial growth plate

Archives of Orthopaedic and Trauma Surgery
B L van LeeuwenH J Hoekstra

Abstract

Tibial bones are shorter and less resistant to shear forces after treatment with doxorubicin, methotrexate, or cisplatin. We investigated the pattern of failure after shear loading of the proximal tibial growth plate in rats treated with these chemotherapeutic agents. Male Wistar rats from the age of 4 weeks were given doxorubicin intravenously at 15 mg/m2 body surface area (BSA), methotrexate 60 mg/m2 BSA, or cisplatin 7.5 mg/m2 BSA. There was one nontreated control group fed ad libitum an d a diet control group for each drug-treated group. At the age of 13 weeks the tibial bones were dissected. The proximal growth plate was shear loaded to failure in the posteroanterior direction. The pattern of failure through the growth plate was examined. In rats fed ad libitum the failure pattern ran mainly through the transitional zone between proliferating and hypertrophic chondrocytes, but the pattern of failure showed considerable variability. The pattern in rats treated with methotrexate or cisplatin and that in their diet controls were comparable. In rats treated with doxorubicin the fracture ran mainly through the trabecular zone. Doxorubicin affects the pattern of failure after shear loading of the proximal tibial growth plate, bu...Continue Reading

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Citations

May 5, 2009·Journal of Cancer Survivorship : Research and Practice·Charles J StavaRena Vassilopoulou-Sellin
Jan 25, 2012·Journal of Toxicologic Pathology·Chihiro NoguchiShigeru Okuyama
Oct 28, 2011·Science Translational Medicine·Vered StearnsSaraswati Sukumar
May 28, 2013·Journal of Biomechanics·Derin SevenlerLawrence J Bonassar

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