Chemotherapy and EGFR tyrosine kinase inhibitors for treatment of brain metastases from non-small-cell lung cancer: survival analysis in 210 patients

OncoTargets and Therapy
Yun FanWeimin Mao

Abstract

Chemotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are controversial in the treatment of patients with brain metastases from non-small-cell lung cancer (NSCLC). We retrospectively studied the effects of solely localized treatment or localized treatment in combination with chemotherapy and/or EGFR tyrosine kinase inhibitors on outcomes in 210 NSCLC patients with brain metastases. The effects of treatment modality, Karnofsky performance status, age, primary tumor histology, number of brain metastases, and other factors on survival time were analyzed, and the robustness of two prognostic indices, ie, recursive partitioning analysis and graded prognostic assessment, was evaluated. The median survival time in patients with systemic medication and localized treatments was higher than in those with localized treatments alone (11 versus 3 months, P=0.000). Within the systemic medication group, median survival time was significantly longer for EGFR tyrosine kinase inhibitors than for other types of chemotherapy (12 versus 9 months, P=0.002). In the EGFR tyrosine kinase inhibitor group, median survival time for patients with EGFR gene mutation was 20 months versus 8 months for those with the wild-type EGF...Continue Reading

Citations

Mar 19, 2014·World Neurosurgery·Muhammad M Abd-El-Barr, E Antonio Chiocca
Sep 24, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Petra HoffknechtUNKNOWN Afatinib Compassionate Use Consortium (ACUC)
Jan 30, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin SchulerJames C-H Yang
May 30, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Michael JuchumStefan A Laufer
May 17, 2015·Current Problems in Cancer·Analiz Rodriguez, Stephen B Tatter
Mar 17, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mi Kyung BaeKyung Young Chung

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BETA
surgical resection

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Statistical Package for the Social Sciences

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