PMID: 9169819Mar 15, 1997Paper

Chemotherapy and low-dose radiotherapy in the treatment of HIV-infected patients with carcinoma of the anal canal

International Journal of Radiation Oncology, Biology, Physics
A V PeddadaA R Kagan

Abstract

To determine the efficacy and tolerance of a standardized protocol of chemotherapy and low-dose radiotherapy in the treatment of anal cancer in human immunodeficiency virus (HIV)-infected patients. Between 1987 and 1995, eight HIV-positive patients with squamous cell carcinoma of the anal canal, four of whom had acquired immunodeficiency syndrome (AIDS), received therapy at the Kaiser Permanente Medical Center. All patients were treated using a combined modality approach consisting of low-dose radiotherapy (30 Gy in 15 fractions delivered 5 days/week), and chemotherapy [1000 mg/m2 of 5-fluorouracil (5-FU) delivered on days 1-4 and 29-32 as a continuous infusion over 96 h, and 10 mg/m2 of mitomycin C delivered as a bolus injection on day 1]. Patients have been followed from 4 to 81 months (mean 41, median 38). All eight patients completed the therapy with minor variations to the protocol, and all have attained a clinical complete response. Four patients are alive and free of disease, and four died as a result of complications of AIDS, but remained free of anal carcinoma. There were no mortalities from the protocol and the morbidity was acceptable. Only one patient each was noted to have Radiation Therapy Oncology Group/European ...Continue Reading

References

Nov 1, 1979·Diseases of the Colon and Rectum·H S CooperG Marks
Feb 1, 1992·Annals of Surgery·R DociG Lamonica
Jan 1, 1991·Acta Oncologica·C SvenssonS Goldman
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B J CummingsC N Catton
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·M Rotman, C S Lange
Apr 1, 1991·Diseases of the Colon and Rectum·H P LorenzW Schecter
Oct 1, 1989·Current Opinion in Oncology·L D Kaplan
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·A M BeckmannT G Hislop
Oct 15, 1987·The New England Journal of Medicine·J R DalingL Corey
Feb 1, 1985·The American Journal of Medicine·L LeichmanC Leichman
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Mar 1, 1981·Diseases of the Colon and Rectum·N D NigroB Considine
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·M HarrisonS Stewart
Sep 1, 1994·Diseases of the Colon and Rectum·M ChadhaA Berson

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Citations

May 2, 2001·Diseases of the Colon and Rectum·R J PlaceC L Simmang
Jun 9, 2009·Diseases of the Colon and Rectum·Melissa E HoggAmy L Halverson
Apr 26, 2005·Current Infectious Disease Reports·Soon Thye Lim, Alexandra M Levine
Sep 10, 2013·Journal of Gastrointestinal Cancer·Joshua E MeyerEdyta C Pirog
Sep 25, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Robert Bryan BarrigerHiginia Rosa Cárdenes
Dec 6, 2000·Annales de chirurgie·D Peiffert
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·R HoffmanR Krieg
Apr 14, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S CleatorM Bower
Mar 7, 2002·Critical Reviews in Oncology/hematology·Umberto TirelliEmanuela Vaccher
Jul 6, 2002·Critical Reviews in Oncology/hematology·Lisa LicitraMichel Ducreux
Nov 14, 1997·Journal of the American College of Surgeons·P R FuchshuberN J Petrelli
Mar 9, 2004·The Lancet Oncology·Matthew A ClarkJ Ian Geh
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J E EfronJ J Nogueras
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E. D. ReisT. Heimann
May 1, 2006·Clinics in Colon and Rectal Surgery·Bruce W Robb, Matthew G Mutch
Mar 16, 2000·The New England Journal of Medicine·D P RyanR J Mayer
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth Y ChiaoHashem El Serag
Mar 30, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Alfa-WaliM Bower
Jul 30, 2011·World Journal of Gastroenterology : WJG·Pascal GervazPhilippe Morel
Jul 11, 2014·Current Treatment Options in Oncology·Shahab Ahmed, Cathy Eng
Dec 21, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ingeborg FraunholzClaus Rödel
Feb 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Chang-Ming ChenKen Dornfeld
Jan 20, 2010·Current Problems in Cancer·Emily ChanCharles R Thomas
Nov 28, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefan EsserUlrike Wieland
Sep 9, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Evan C WhiteAroor R Rao
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Paul HatfieldDavid Sebag-Montefiore
May 24, 2001·Hematology/oncology Clinics of North America·A K Chawla, C G Willett
Jul 11, 2003·Hematology/oncology Clinics of North America·Barbara J Klencke, Joel M Palefsky
May 13, 2004·Surgical Oncology Clinics of North America·Dennis L RousseauMorton S Kahlenberg
May 13, 2004·Surgical Oncology Clinics of North America·J Michael BerryMark Lane Welton
Aug 7, 2003·Cancer Investigation·James E Gervasoni, Harold J Wanebo
Oct 5, 2001·Arquivos De Gastroenterologia·A P GuimarãesN M Forones
Oct 7, 2003·Oncogene·Massimiliano BerrettaUmberto Tirelli
Mar 31, 2005·British Journal of Cancer·N CharnleyD Sebag-Montefiore
Jun 18, 2002·The Oncologist·Natia EsiashviliRichard H Matthews
May 25, 2007·The Oncologist·Hope E Uronis, Johanna C Bendell
Jul 11, 2000·Current Opinion in Oncology·D P Ryan, R J Mayer
Dec 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph A SparanoRonald Mitsuyasu

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