PMID: 6680224Nov 1, 1983Paper

Chemotherapy and radiotherapy for advanced testicular non-seminoma. I. The influence of sequence and timing of drugs and radiation on the appearance of normal tissue damage

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
J YarnoldM J Peckham

Abstract

Acute and delayed normal tissue damage has been investigated in 63 advanced stage testicular non-seminoma patients receiving elective involved-field irradiation after chemotherapy and in 53 patients who had chemotherapy given for relapse after prior irradiation. The risk of death from complications due to chemotherapy was 0% and 9.4% (p less than 0.025) in the two groups respectively. Gastro-intestinal damage and/or subcutaneous fibrosis was present in 12.6% and 24.5% of patients respectively, although only three patients have serious persisting disability. In patients receiving 35-45 Gy to the retroperitoneum the incidence of normal tissue damage was 0% and 25% (p less than 0.001), respectively. In addition to the sequence in which chemotherapy and radiotherapy was delivered, the time interval between completion of radiotherapy and start of chemotherapy was important with 6/6 patients receiving drugs within 2 months of irradiation developing fibrosis. Abdominal surgery appeared not to influence the risk of damage. Of nine patients receiving drugs after infradiaphragmatic and supra-diaphragmatic irradiation two died of neutropenic sepsis.

References

Dec 1, 1976·Cancer Treatment Reviews·M L SamuelsD E Johnson
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Citations

Jun 1, 1986·International Journal of Radiation Oncology, Biology, Physics·F StewartH Bartelink
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P HjiYiannakis, J R Yarnold
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P HjiYiannakis, J R Yarnold
Jan 1, 1985·Acta Radiologica. Oncology·O Dahl
Jun 1, 1992·International Journal of Radiation Biology·S J Falk, P J Smith
Jul 18, 2021·International Journal of Clinical Oncology·Giulio FrancoliniStefano Arcangeli

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