Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: a review

Head & Neck
Giorgos PapaspyrouAlfio Ferlito

Abstract

Adenoid cystic carcinoma (ACC) is an uncommon tumor usually arising in the head and neck region, mainly in the salivary glands. It demonstrates an indolent prolonged course and is characterized by perineural invasion. Primary treatment of local and locoregional disease consists mainly of surgery and/or irradiation. During follow-up these patients frequently develop local recurrences and distant metastases, especially in the lung, although long-term survival is possible. The role of chemotherapy in ACC is limited, and studies with only a limited number of patients are performed. In this article we review the literature on chemotherapy regimens, including monotherapy and combination chemotherapy schedules, as well as the new targeted therapies.

References

Oct 1, 1977·The Laryngoscope·J L Pulec
Apr 1, 1979·Cancer·W L Marsh, M S Allen
Dec 1, 1992·American Journal of Surgery·R H Spiro, A G Huvos
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I W DimeryW K Hong
Jan 1, 1988·Medical and Pediatric Oncology·C P BelaniW C Gray
Jun 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D J Howard, V J Lund
Aug 1, 1974·Archives of Otolaryngology·J Conley, D L Dingman
Oct 1, 1974·American Journal of Surgery·R H SpiroE W Strong
Jul 1, 1980·Archives of Otolaryngology·R H Miller, T C Calcaterra
Aug 1, 1980·Cancer·I F Tannock, D J Sutherland
Dec 1, 1981·Archives of Otolaryngology·V L SchrammE N Myers
Mar 1, 1982·The Laryngoscope·J Y Suen, M E Johns
Feb 1, 1984·International Journal of Radiation Oncology, Biology, Physics·B VikramR H Spiro
Nov 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J B VermorkenG B Snow
Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L LicitraR Molinari
Oct 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J VerweijJ L Lefebvre
Mar 24, 1998·The Journal of Laryngology and Otology·A ShadabaH R Grant
Feb 26, 1999·Archives of Otolaryngology--head & Neck Surgery·J FordiceH Goepfert
Oct 8, 1999·American Journal of Otolaryngology·E P ProkopakisF D'Amico
Oct 13, 2000·International Journal of Oral and Maxillofacial Surgery·C M AveryJ D Langdon
Nov 19, 2003·Indian Journal of Pediatrics·Vasantha ThavarajL S Arya
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sébastien J HotteLillian L Siu
Jul 2, 2005·International Journal of Clinical Oncology·Masakazu NishidaKenji Kashima
Aug 24, 2005·International Journal of Clinical Practice·N KaraoglanogluN Gursan
Nov 16, 2005·Acta otorrinolaringológica española·G Sequeiros SantiagoC Suárez Nieto
Nov 23, 2006·Archives of Otolaryngology--head & Neck Surgery·Pascal PommierAnnie W Chan

❮ Previous
Next ❯

Citations

Oct 12, 2012·Frontiers of Medicine·Jin GaoAlan R Clough
Jan 5, 2012·Current Treatment Options in Oncology·M Boyd GillespieDavid W Eisele
Nov 29, 2013·Archives of Pathology & Laboratory Medicine·Ronghui XiaJiang Li
May 6, 2014·The British Journal of Oral & Maxillofacial Surgery·Rory O'ConnorPeter A Brennan
Oct 28, 2014·The Journal of Craniofacial Surgery·Kyoungyoon ShinSungeun E Kyung
Oct 5, 2012·Ophthalmic Plastic and Reconstructive Surgery·Ryan D WalshMadhura A Tamhankar
Dec 2, 2015·Oncology Letters·Guanqiao LiShiping Yang
Dec 22, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jonathan W ShumRobert A Ord
Jul 31, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Christopher-Philipp NobisMarco R Kesting
Dec 1, 2012·Surgical Pathology Clinics·Jennifer L Hunt
Jun 1, 2012·International Journal of Oral and Maxillofacial Surgery·R MinZ Chenping
Jun 13, 2012·Seminars in Radiation Oncology·David J AdelsteinEhab Y Hanna
Oct 1, 2012·Practical Radiation Oncology·Gabriel O de la GarzaJohn M Buatti
Apr 4, 2013·Taiwanese Journal of Obstetrics & Gynecology·Shih-Tien HsuEsther Shih-Cho Ho
Oct 22, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Li-Jun LiuBing Chen
Feb 9, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Ajeet Kumar GandhiBidhu Kalyan Mohanti
Jun 23, 2015·The Journal of Pathology·Luciano G MartelottoBritta Weigelt
Dec 10, 2014·Head & Neck·Patrick M DillonChristopher Y Thomas
Apr 4, 2015·Virchows Archiv : an International Journal of Pathology·Karoliina HirvonenAntti A Mäkitie
Jun 12, 2013·European Annals of Otorhinolaryngology, Head and Neck Diseases·G MichelO Malard
Sep 1, 2011·Otolaryngologia polska. The Polish otolaryngology·Antoni BruzgielewiczKazimierz Niemczyk
May 2, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L AfaniY Lalami
Oct 12, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jun JuMoyi Sun
Jan 21, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley
Sep 9, 2018·The Laryngoscope·Richard J CassidyJonathan J Beitler
Feb 7, 2018·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Yi-Chan LeeKai-Ping Chang
Jul 31, 2012·Oral and Maxillofacial Surgery·Tobias EttlTorsten E Reichert
Jun 27, 2013·British Journal of Cancer·S V IvanovW G Yarbrough
Sep 14, 2017·Acta Oto-laryngologica·Shinji TakebayashiKoichi Omori
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L Hunt
Jun 11, 2017·Virchows Archiv : an International Journal of Pathology·Hanna HämetojaLeif Bäck
Aug 1, 2012·Clinical & Experimental Metastasis·Daisuke UchidaYouji Miyamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.