Chemotherapy-associated oral mucosal lesions in patients with leukaemia or lymphoma

European Journal of Cancer. Part B, Oral Oncology
Velia Ramírez-AmadorG Sánchez-Mejorada

Abstract

In order to determine the incidence rate of oral lesions associated with chemotherapy, as well as well as its association with clinical and laboratory parameters and potential risk factors, 50 in-patients with non-Hodgkin's lymphoma or leukaemia under chemotherapy were followed from January 1993 to May 1994. Basal and weekly oral examinations were performed. Clinical and laboratory data were registered. Wilcoxon's rank sum test, chi square test, univariate and multivariate logistic regression analyses were used, 36 individuals with leukaemia and 14 with non-Hodgkin's lymphoma were followed for 158 weeks; mean age was 33 years (range 15-85). Oral lesion incidence rate was 45/100 patients-week. Exfoliative cheilitis and infections (herpes and candidosis) were the most common oral complications, followed by haemorrhagic lesions and mucositis. Haemorrhagic lesions correlated with thrombocytopenia (RR = 30.5). Etoposide administration (RR = 8.6), alkylating agents (RR = 15.6), a prior course of chemotherapy (RR = 23.2) and neutropenia (RR = 4.16) were predictors of mucositis. Oral lesions were a common complication in this study, and a possible association of mucositis with several factors is suggested.

References

Sep 1, 1978·The Journal of the American Dental Association·S T SonisA Lieberman
Aug 1, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·G M McCarthy, J R Skillings
Dec 11, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·S T SonisM Nicolson
Aug 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C Scully, O P de Almeida
Sep 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·Y B WahlinM Sjöström
Jan 1, 1991·Cancer·R H Herzig
Jul 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·J B EpsteinG Phillips
Dec 1, 1989·Oral Surgery, Oral Medicine, and Oral Pathology·A HeimdahlO Ringdén
Aug 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·A P BarrettM J Earl
Jul 1, 1987·Oral Surgery, Oral Medicine, and Oral Pathology·J A PhelanR S Klein
Dec 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·S DreizenM J Keating
Nov 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·B G SetoR Champlin
May 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·S DreizenM J Keating
Feb 1, 1981·Oral Surgery, Oral Medicine, and Oral Pathology·A SpielmanE Deutsch
Jun 1, 1993·Cancer Metastasis Reviews·S RockwellK A Kennedy
Jan 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·N K ChildersA P Dasanayake
Apr 7, 1993·Journal of the National Cancer Institute·R C Jackson
Oct 1, 1993·European Journal of Cancer. Part B, Oral Oncology·P O LaineJ H Meurman
Jan 1, 1964·The Journal of the American Dental Association·J C GREENE, J R VERMILLION

❮ Previous
Next ❯

Citations

Aug 5, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Karis K F ChengDavid R Thompson
May 8, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rajesh V LallaUNKNOWN Fungal Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/Internation
Jun 15, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sharon EladUNKNOWN Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/Internationa
Apr 28, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K K F ChengM P Yuen
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K K ChengS S Cheung
Mar 3, 2011·International Journal of Paediatric Dentistry·Naïma OtmaniMohammed Khattab
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Saif KhanAfshan Bey
Aug 1, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·V Ramirez-AmadorJ Quivey
May 29, 2020·Biomédica : revista del Instituto Nacional de Salud·Elba G Rodríguez-PérezKevin Escandón-Vargas
Nov 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sharon EladUNKNOWN Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/Internationa
Sep 28, 2017·Journal of Clinical Pharmacy and Therapeutics·V Ramírez-AmadorS Ponce de León-Rosales

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
M Bonnaure-MalletE LeGall
Oral Surgery, Oral Medicine, and Oral Pathology
N K ChildersA P Dasanayake
Cancer Chemotherapy and Pharmacology
Y KubotaM Watanabe
© 2021 Meta ULC. All rights reserved