Chemotherapy during pregnancy

Current Opinion in Oncology
Frédéric AmantKristel Van Calsteren

Abstract

Cancer during pregnancy is uncommon, although not rare. As women in developed societies defer childbearing and the incidence of most malignancies rises with increasing age, the situation in which cancer complicates pregnancy is expected to become more common. Cancer staging and treatment can be performed during pregnancy and should be defined in a multidisciplinary setting. Here, we describe the potential to use chemotherapy during pregnancy. New insights add to the practice of administering chemotherapy from 14 weeks gestational age onwards. The placental barrier function protects the fetus. The physiologic gestational changes reduce the maternal serum levels of chemotherapy, although the pharmacodynamic impact remains unknown. Comedication to chemotherapy can be administered on strict indications. Chemotherapy after 35 weeks is not recommended as an interval of at least 3 weeks is preferred between chemotherapy administration and delivery. Recent data show that the long-term outcome of children antenatally exposed to chemotherapy is comparable to children of the same age. Nevertheless, a higher rate of neurodevelopmental problems was encountered after preterm birth, also in this selected patient population. Administration of ...Continue Reading

Associated Clinical Trials

References

Feb 1, 1977·American Journal of Obstetrics and Gynecology·A T Blanford, B E Murphy
Jan 1, 1980·Pharmacology & Therapeutics·B KrauerF E Hytten
Sep 1, 1997·Obstetrics and Gynecology Clinics of North America·J I SoroskyT E Buekers
Aug 15, 2000·American Journal of Obstetrics and Gynecology·C Achtari, P Hohlfeld
Jan 22, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·M Dawes, P J Chowienczyk
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GermannF Goldwasser
May 4, 2004·The Lancet Oncology·Elyce Cardonick, Audrey Iacobucci
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alistair E RingPaul A Ellis
Nov 8, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A AvilésM J Nambo
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristel Van CalsterenXavier De Muylder
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 10, 2007·Journal de gynécologie, obstétrique et biologie de la reproduction·L DessolleE Daraï
Jul 27, 2007·Cardiovascular Toxicology·Billy ChenDouglas B Sawyer
Dec 20, 2007·Journal of Neuropathology and Experimental Neurology·Daniela VirgintinoLuisa Roncali
Nov 26, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanne StensheimSophie D Fosså
Feb 12, 2009·Onkologie·Anne K BaumgärtnerS Pildner von Steinburg
Oct 21, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristel Van CalsterenFrédéric Amant
Dec 25, 2009·European Radiology·Els L van Persijn van MeertenJohan L Bloem
Feb 19, 2010·The Cancer Journal·Elyce CardonickAniqa Usmani
Sep 10, 2010·Reproductive Sciences·Kristel Van CalsterenFrédéric Amant
Sep 18, 2010·Acta Obstetricia Et Gynecologica Scandinavica·Kristel Van CalsterenFrédéric Amant
Oct 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frédéric AmantAndreas Du Bois
Dec 24, 2010·Developmental Medicine and Child Neurology·Gro C C LøhaugenJon Skranes
Feb 19, 2011·Cardiology Research and Practice·Vivian I FrancoSteven E Lipshultz
Oct 28, 2011·Clinical Obstetrics and Gynecology·Janelle R Walton, Mona R Prasad
Feb 14, 2012·Lancet·Frédéric AmantKristel Van Calsteren

❮ Previous
Next ❯

Citations

Jul 14, 2016·Journal of Advanced Research·Sotirios MitrouNicholas Pavlidis
Jun 16, 2015·ANZ Journal of Surgery·Danielle E RobsonDavid J Cavallucci
Mar 24, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Frédéric AmantKristel Van Calsteren
Nov 6, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Arunachalam Ilancheran
Oct 5, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S BoussiosF Amant
Feb 11, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Erin A BlakeKoji Matsuo
Jun 11, 2016·Japanese Journal of Clinical Oncology·Shingo MiyamotoKazumichi Andoh
Aug 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sacha I Rothschild
Jul 9, 2014·Obstetrics and Gynecology·Eric C T GeijtemanLia van Zuylen
Sep 11, 2020·JCO Oncology Practice·Jordyn SilversteinKatherine Van Loon
Mar 28, 2018·Cancer Biology & Therapy·Yuanyuan ChenFengxia Xue
May 8, 2021·International Journal of Paediatric Dentistry·Neel S IyerElyce Cardonick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Obstetricia Et Gynecologica Scandinavica
Kristel Van CalsterenFrédéric Amant
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Nesrin SarımanAttila Saygı
© 2021 Meta ULC. All rights reserved