PMID: 8950335Jan 1, 1997Paper

Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials

Medical and Pediatric Oncology
L VainionpääM Lanning

Abstract

Intrathecal chemotherapy has been determined to cause transient or permanent paraparesis due to myelopathy in patients with leukemia or other malignancies. To systematically evaluate the effect of methotrexate on spinal cord function, somatosensory evoked potentials (SEP) were measured in children with acute lymphoblastic leukemia (ALL). A prospective evaluation was performed in 38 consecutive children aged 1.4-15.3 years with newly diagnosed ALL during treatment. Intrathecal methotrexate therapy was included in the therapy schedule of all patients as central nervous system (CNS) therapy in addition to intravenous chemotherapy in 19 standard risk patients and intravenous chemotherapy with cranial irradiation in 19 intermediate or high-risk patients. The measured conduction times were compared with those of 38 control children matched for age, height, and sex. A significant increase in the conduction time of the tibial nerve SEP was found between the Th12 level and the cortex in children with ALL after receiving intrathecal methotrexate therapy during the induction and CNS therapy phases when compared with their controls. The difference of the mean latencies was 1.45 ms (95% CI 0.39-2.51; P < 0.01). There was no significant dela...Continue Reading

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Citations

Jun 1, 2010·Pakistan Journal of Biological Sciences : PJBS·A A G TantawyA A N A El Aziz
Oct 24, 2007·Journal of the Neurological Sciences·Ana M PascualMiguel J A Láinez
Oct 31, 2015·Journal of Pediatric Psychology·Lyn M BalsamoNina S Kadan-Lottick
Oct 5, 2013·The Journal of Spinal Cord Medicine·Prathap Jacob Joseph, Maria Regina Reyes
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ching-Hon Pui
Nov 11, 2016·Scientific Reports·Einar-Jón EinarssonChristian Moëll
Nov 26, 1999·Medical and Pediatric Oncology·H Reinders-MesselinkW Kamps
Jan 15, 1998·Cancer·A H Harila-SaariB M Lanning
May 14, 2005·Journal of Pediatric Hematology/oncology·Ali BayHuseyin Caksen
Mar 29, 2019·Bulletin of Environmental Contamination and Toxicology·Li LiuZhi-Hong Wang

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