Chemotherapy for Muscle-Invasive Bladder Cancer

Current Treatment Options in Oncology
Patrizia TrentaCora N Sternberg

Abstract

In the last 25 years, there has been an improved understanding of the pathogenesis of muscle-invasive bladder cancer (BC). Development of new treatment strategies has followed. We have progressed from the awareness of the efficacy of platinum compounds, especially cisplatin, as single agents to the development of effective drug combinations with greater attention in improving safety profiles while impacting on survival. Peri-operative chemotherapy (CHT) is the standard of care for non-metastatic disease. The most evidence in terms of a survival advantage is derived from neoadjuvant chemotherapy (NC) trials, but adjuvant medical treatment should be strongly considered when NC has not been utilized. Patient selection and a multidisciplinary approach are essential. Platinum-based CHT is still the standard of care for both early and advanced disease. A deeper knowledge of the pathogenesis of BC will derive from gene expression profiling (GEP), and this will give us new prognostic and predictive tools to develop more targeted treatments. A high mutational rate has been observed in BC, which can generate neoantigens that initiate cancer immunity. Immunotherapy will become a pivotal treatment for BC, in the very near future. Emerging ...Continue Reading

References

Jul 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J LoehrerB A Lowe
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J LogothetisR G Kilbourn
Oct 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J LogothetisK I Wishnow
Aug 1, 1987·Cancer·A Yagoda
Nov 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M CoppinL D Sullivan
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F BajorinM G Boyle
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BellmuntJ Baselga
Sep 21, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Sylvester, C Sternberg
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C N SternbergUNKNOWN European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A MeluchJ D Hainsworth
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ShannonH Gurney
Mar 8, 2003·Scandinavian Journal of Urology and Nephrology·Amir SherifUNKNOWN Nordic Urothelial Cancer Group
Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jinxing LiChristopher J Sweeney
Jun 11, 2005·The Journal of Urology·Jonathan E RosenbergEric J Small
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Jan 18, 2006·International Journal of Clinical Practice·G FechnerUNKNOWN German Association Of Urologic Oncology (Auo) Bladder Cancer Study Group
Feb 17, 2009·World Journal of Urology·Martine PloegLambertus A Kiemeney
Aug 19, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joaquim BellmuntHans von der Maase
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joaquim BellmuntJonathan E Rosenberg
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Collaboration of TrialistsMahesh K B Parmar
Aug 25, 2012·European Urology·Georgios GakisUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Apr 2, 2013·The Urologic Clinics of North America·Andrew C James, John L Gore

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Citations

Aug 16, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shu-Xiong ZengChong-Xian Pan

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