Chemotherapy for neuroendocrine tumors: the Beatson Oncology Centre experience

Clinical Oncology : a Journal of the Royal College of Radiologists
M Q Hatton, N S Reed

Abstract

The role of chemotherapy in malignant neuroendocrine tumours is difficult to assess because of their rarity and variation in biological behaviour. We present a retrospective review of chemotherapy given to 18 patients with metastatic and one with locally advanced neuroendocrine tumours. There were eight poorly differentiated neuroendocrine tumours, six thyroid medullary carcinomas, two phaeochromocytomas, two pancreatic islet cell tumours and one undifferentiated neuroblastoma. Four patients were given 3-weekly dacarbazine, vincristine and cyclophosphamide (DOC) chemotherapy. In eight patients, this regimen was modified by substituting the dacarbazine and cisplatin and etoposide (OPEC). A further six patients were treated with dacarbazine reintroduced into the 3-weekly regimen (DOPEC). The remaining patient received cisplatin and etoposide. There were two complete responses (both with OPEC) and eight partial responses (two with DOC, three with OPEC and three with DOPEC). Five patients had stable disease and four progressed. Four received further chemotherapy on relapse, producing one complete and one partial response. The median response duration to initial chemotherapy was 10 months (range 3-34). The median survival was 12 mon...Continue Reading

Citations

Apr 21, 2012·International Journal of Hepatology·Ron BasuroyJohn K Ramage
Aug 8, 2015·Cancer Metastasis Reviews·P Jiménez-FonsecaUNKNOWN Spanish Neuroendocrine Tumor Group (GETNE)
Aug 24, 2005·Cancer·Lloyd H SmithPatrick S Romano
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Jul 19, 2013·British Journal of Cancer·W C C SzeM R Druce
Aug 10, 1999·American Journal of Clinical Oncology·T Mahmood, R Mudad
Sep 6, 2018·Annals of Surgical Oncology·David StrosbergLawrence A Shirley
Dec 11, 1999·Clinical Oncology : a Journal of the Royal College of Radiologists·N S Reed

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