PMID: 9447624Feb 3, 1998Paper

Chemotherapy for pediatric brain tumors

Seminars in Pediatric Neurology
A Kedar

Abstract

Advances have recently been made in the use of chemotherapy for pediatric brain tumors. Chemotherapy increases disease-free survival in high-risk primitive neuroectodermal tumor/medulloblastoma patients and enables the reduction of radiation therapy in standard-risk patients. Radiation can be significantly delayed and neurotoxicity ameliorated in many infants using chemotherapy. Chemotherapy can cause reduction in size of low-grade glioma, optic glioma, and oligodendroglioma. High-grade glioma and ependymoma are relatively chemoresistant. Physicians caring for children with brain tumors are encouraged to participate in controlled studies, so that objective information can be gathered and the role of chemotherapy in these tumors can be better defined.

References

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Citations

Jul 19, 2002·Paediatric and Perinatal Epidemiology·Johan ReutforsAnders Ahlbom
Oct 31, 2002·Journal of Child Neurology·Tena Rosser, Roger J Packer
Mar 20, 1999·Current Opinion in Pediatrics·J B Rubin, M W Kieran
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ozlem OzenJochen Herms

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