Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma

Annals of Surgical Oncology
John T MiuraT Clark Gamblin

Abstract

The benefit of chemotherapy for surgically resected intrahepatic cholangiocarcinoma (ICC) remains poorly defined. The present study sought to determine the survival impact of chemotherapy for surgically resected ICC. Patients with non-metastatic ICC who underwent surgery were identified from the National Cancer Database (1998-2011) and stratified by receipt of chemotherapy. Survival outcomes were analyzed following propensity score modeling using the greedy matching algorithm. A total of 2751 patients were identified (median age 64 years); 985 (35.8 %) received chemotherapy. Younger age, advanced tumor stage, R1/R2 surgical margins, and lymph node metastasis were all independently associated with receipt of chemotherapy (p < 0.05). Following propensity score matching, advanced tumor stage, lymph node metastasis, poorly differentiated tumors, and R1/R2 surgical margins were associated with poorer overall survival (OS) (p < 0.05). Median OS comparing patients who received chemotherapy compared with surgery alone was 23 versus 20 months (p = 0.09). However, when stratified by lymph node status, chemotherapy demonstrated a significant improvement in median OS among N1 patients (19.8 vs. 10.7 months; p < 0.001). In contrast, patient...Continue Reading

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Citations

Jan 16, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giovanni BrandiUNKNOWN GICO
Sep 14, 2016·Journal of Cellular and Molecular Medicine·Zheng LiWilliam Ka Kei Wu
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Feb 13, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jonathan G NavarroJin Sub Choi

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