PMID: 16632978Apr 25, 2006Paper

Chemotherapy in rectal cancer

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Joong Bae Ahn

Abstract

Until mid-1990s, fluorouracil was the only chemotherapeutic agent available for the treatment of colorectal cancer. The treatment of advanced colorectal cancer has evolved considerably over the last decade. Considerable improvements in survival as well as quality of life have been achieved with the application of oxaliplatin and irinotecan with fluoropyrimidine as a first and subsequent line therapy for colorectal cancer. Development of oral fluoropyrimidines as an alternative to intravenous administration provides an additional option for combination cytotoxic therapy, which is currently being assessed in phase III trials in advanced settings. The appearance of biologic agents in mid-2000s, namely cetuximab and bevacizumab, and their integration with conventional cytotoxic therapy for the treatment of colorectal cancer has additionally expanded the options for the treatment. Their dramatic success has led to further clinical studies of targeted therapy in colorectal cancer, making it one of the most promising areas of cancer research. Although considerable improvement was achieved by incorporating oxaliplatin in adjuvant chemotherapy for the treatment of colon cancer, there has been no phase III trial incorporating new agents ...Continue Reading

References

Sep 19, 1990·JAMA : the Journal of the American Medical Association
Jun 6, 1985·The New England Journal of Medicine·UNKNOWN Gastrointestinal Tumor Study Group
May 31, 2001·International Journal of Radiation Oncology, Biology, Physics·G J FrykholmB Glimelius
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E TepperR J Mayer
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer

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Citations

Nov 11, 2009·Annals of Surgical Innovation and Research·Marco CoccettaFrancesco Sciannameo
Feb 4, 2010·Physics in Medicine and Biology·Wendy SmithDelia Pudney
Nov 8, 2011·Physics in Medicine and Biology·Geetha MenonWendy Smith

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