PMID: 8613975Feb 1, 1995Paper

Chemotherapy-induced hemolytic uremic syndrome: description of a potential animal model

Journal of Medical Primatology
C D HillyerE F Winton

Abstract

Hemolytic uremic syndrome (HUS) is an uncommon complication of chemotherapy that contributes to the morbidity of oncology and bone marrow transplant patients. The pathogenesis is not well understood and no established clinical animal model exists. We studied four rhesus monkeys (RM) that developed fatal HUS following high-dose chemotherapy. Microangiopathic hemolytic anemia (pre-Hct 40% and day 5-8 Hct 31% (P < .05), increased BUN (168 mg/dl), creatinine (8.2 mg/dl), and lactate dehydrogenase (1458 IU/L) (mean day 5-8 measurements) were observed. Platelets counts decreased to 39 +/- 15 x 10(9)/l from a mean of 397 +/- 31 x 10(9)/L (P < .0001). vWF, ATIII, thrombin:anti-thrombin complex (T:AT) and prothrombin fragment F1.2 levels were not different from a control group (N = 2). The data presented describe chemotherapy-induced HUS with typical clinical and laboratory features which may provide an animal model for the study of this important syndrome.

References

Nov 1, 1992·Annals of Hematology·A Cerveró MartiM Sanchez
Jan 1, 1992·International Journal of Clinical & Laboratory Research·D Ciavarella
Mar 1, 1990·American Journal of Diseases of Children·K J ShethH E Leichter
May 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W L RobsonA K Leung
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D HébertM S Mauer
Apr 1, 1990·Kidney International·B TönshoffH W Seyberth
May 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B S KaplanT G Obrig
Jun 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J B LesesneP S Schein
Nov 1, 1981·Human Pathology·S RosenR Habib
Apr 1, 1981·Kidney International·M Beaufils
Feb 16, 1980·British Medical Journal·P BrandtG Gregersen

❮ Previous
Next ❯

Citations

Jan 4, 1998·Kidney International·H A Repetto
Nov 20, 2002·Bone Marrow Transplantation·A S DalyJ H Lipton
Aug 26, 1998·Renal Failure·R M Viero, V A Soares
Apr 30, 2017·Oncology Letters·Florence Lai-TiongFrancois Krabansky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.