Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy

Annals of Hematology
Kevin KempCraig Donaldson

Abstract

Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage mature bone marrow stromal cells in vitro, but the extent to which marrow mesenchymal stem cells (MSCs) are damaged by HDC in vivo is largely unknown. To address this question, the phenotype and functional properties of marrow MSCs derived from untreated and chemotherapeutically treated patients with hematological malignancy were compared. This study demonstrates a significant reduction in MSC expansion and MSC CD44 expression by MSCs derived from patients receiving HDC regimens, thus implicating potential disadvantages in the use of autologous MSCs in chemotherapeutically pretreated patients for future therapeutic strategies. The clinical importance of these HDC-induced defects we have observed could be determined through prospective randomized trials of the effects of MSC cotransplantation on hematopoietic recovery in the setting of HDC with and without hematopoietic stem cell rescue.

References

Jun 1, 1977·Journal of Cellular Physiology·T M DexterL G Lajtha
Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Apr 1, 1989·Journal of Immunogenetics·A P GeeM Weiler
Jan 1, 1987·Annual Review of Cell Biology·T M Dexter, E Spooncer
Nov 1, 1996·Journal of Leukocyte Biology·S KhaldoyanidiM Zöller
Sep 3, 1998·The Journal of Clinical Investigation·J MollP Herrlich
Apr 2, 1999·Science·M F PittengerD R Marshak
May 3, 2000·Journal of Hematotherapy & Stem Cell Research·J S ReeseS L Gerson
Oct 31, 2000·Current Opinion in Hematology·S M Devine, R Hoffman
Jul 19, 2001·Annals of the New York Academy of Sciences·W E FibbeR Willemze
Oct 20, 2004·British Journal of Haematology·Jing LiGodfrey Chi Fung Chan

❮ Previous
Next ❯

Citations

Jul 12, 2012·International Journal of Hematology·Satoshi NishiwakiTomoki Naoe
Dec 25, 2012·International Journal of Hematology·Rong-Jia ZhuKai-Yan Liu
Jan 10, 2012·Blood·Jeffery J AulettaAmelia M Bartholomew
Jul 10, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Zibin GaoYongjun Sun
Dec 6, 2011·Cellular Immunology·Hanyu WangYongjun Liu
Mar 30, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Emiko HoriSatoshi Kuroda
Aug 13, 2013·International Journal of Pharmaceutics·Tian DaiZibin Gao
Aug 19, 2014·Cytokine & Growth Factor Reviews·Linda J Bendall, Kenneth F Bradstock
Oct 11, 2016·Stem Cells International·Anna Julie PeiredPaola Romagnani
Jan 9, 2017·Blood·Claudia Korn, Simón Méndez-Ferrer
Jun 24, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Jan Lesensky, Daniel E Prince
Apr 29, 2014·World Journal of Stem Cells·Michalis MastriTechung Lee
Jun 23, 2018·International Journal of Cancer. Journal International Du Cancer·Alexander RühleNils H Nicolay
Jan 21, 2018·Journal of Biomedical Science·Chinnapaka SomaiahBithiah Grace Jaganathan
Apr 12, 2013·Experimental Hematology & Oncology·Fung Kwong-Lam, Chan Godfrey Chi-Fung
May 7, 2013·Nature Medicine·Daniel LucasPaul S Frenette
Aug 31, 2018·Journal of Experimental & Clinical Cancer Research : CR·Chao TangCai-Wen Duan
May 10, 2020·International Journal of Hematologic Oncology·Hana Geres, Rouslan Kotchetkov
Nov 24, 2020·Cancer Investigation·Hassan RafieemehrNajmaldin Saki
Sep 17, 2020·Journal of Geriatric Oncology·Jaidyn MuhandiramgeJohn Zalcberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.