Chemotherapy-induced myelotoxicity and incidence of lung metastasis in an animal model

Human & Experimental Toxicology
Jin-Young SonChang-Gue Son

Abstract

We examined how chemotherapy-induced myelotoxicity and the associated leukopaenia affect cancer metastasis in an animal model. Myelotoxicity was induced by a single injection of 5-fluorouracil (5-FU) or Cisplatin, administered to 7-week-old BALB/c mice. CT-26 murine colon carcinoma cells were injected into the lateral tail vein on days 0, 1, 3, 5, and 7 after anticancer drug injection. On day 14 after cancer cell injection, the number of pulmonary colonies was measured in a double-blind setting. Compared with Cisplatin, 5-FU induced severe leukopaenia and bone marrow suppression, while on day 5, both drugs induced severe myelotoxicity. The number of pulmonary colonies did not correlate with the severity of leukopaenia, regardless of the type or time of drug injection, except in the group pretreated with Cisplatin (3 days prior to cancer cell injection). Our results suggest that chemotherapy-induced myelotoxicity does not increase the incidence of cancer metastasis in this animal model.

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Citations

Jul 20, 2011·Clinical & Experimental Metastasis·Jang Woo ShinChang Gue Son
Jun 14, 2018·American Journal of Physiology. Renal Physiology·L M BlackA Agarwal
Apr 26, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Marília Berlofa VisacriPatricia Moriel
Mar 9, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hyo-Seon KimChang-Gue Son

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