Chemotherapy-Induced Neutropenia as a Prognostic and Predictive Marker of Outcomes in Solid-Tumor Patients

Drugs
Pashtoon Murtaza Kasi, Axel Grothey

Abstract

Chemotherapy-induced neutropenia (CIN) is one of the most common side effects seen in cancer patients. As an adverse event, it is deemed undesirable since it often constitutes a dose-limiting toxicity for cytotoxic agents leading to treatment delays and/or dose reductions. It is also associated with a financial cost component from diagnostic work-up and treatment of patients with chemotherapy-induced febrile neutropenia (CIFN). Neutropenia is commonly accompanied by a decrease in other hematopoietic lineages (anemia and/or thrombocytopenia). Dosing of chemotherapeutic agents is based on the severity of adverse effects seen. Depending on the degree of neutropenia, chemotherapeutic agents may be put on hold until count recovery and growth factor support might be added to allow for dosing as scheduled. However, neutropenia appears to be more than just an adverse event. While CIFN by itself constitutes an adverse event, the appearance of just CIN is not necessarily a marker of poor outcome. In fact, it rather appears to be a surrogate marker of response and/or survival in patients treated with cytotoxic regimens. Here we present evidence in different tumor types treated with different regimens on the role CIN plays as a marker for ...Continue Reading

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Citations

Apr 26, 2020·Current Opinion in Supportive and Palliative Care·Elisa N HofmeisterPasquale F Innominato
Dec 23, 2019·International Journal of Clinical Pharmacy·Masataka NomuraMitsuhiko Miyamura
May 23, 2021·Journal of Infection and Public Health·Claudia Rita CorsoDaniele Maria-Ferreira
Jan 9, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P M Kasi, A Grothey
Aug 7, 2021·Pharmaceuticals·Mashiro OkunakaYoshihiro Uesawa

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