Chemotherapy-induced ovarian failure in young women with early breast cancer: Prospective analysis of four randomised neoadjuvant/adjuvant breast cancer trials.

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jenny FurlanettoSibylle Loibl

Abstract

Young women receiving chemotherapy for early breast cancer (EBC) have a high probability for ovarian failure, defined by chemotherapy-induced amenorrhea (CIA) as a surrogate. CIA is insufficiently reliable and reproducible. We analysed chemotherapy-induced ovarian failure (CIOF) by assessing hormone parameters, CIA, and antral follicle count (AFC). Blood samples of women aged ≤45 years treated with anthracycline/taxane-based chemotherapy for EBC from four neoadjuvant/adjuvant trials were collected at baseline, at the end of treatment (EOT), and at 6, 12, 18, and 24 months after EOT. Centrally assessed oestradiol (cutoff <52.2 ng/L) and follicle-stimulating hormone (cutoff >12.4IU/L) were used to define CIOF for patients with baseline premenopausal hormone levels, anti-Müllerian hormone (AMH), and AFC to assess ovarian reserve. Further analyses included CIA, regain of premenopausal hormone levels, and disease-free survival (DFS) also in subgroups. Six hundred ninety-six patients aged ≤45 years had premenopausal hormone levels at baseline. Overall, 85.1% (592/696) experienced CIOF at EOT, and 147 of 592 had further hormone measurements after EOT. Of those, 32.7% (48/147) regained premenopausal hormone levels after 6 months, 57.9%...Continue Reading

References

Dec 1, 2004·Human Reproduction Update·Kerryn Lutchman SinghRatna Chatterjee
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Breast Cancer Study GroupRichard D Gelber
Aug 8, 2006·Human Reproduction Update·F J BroekmansC B Lambalk
Nov 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice M WalsheSandra M Swain
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clifford A HudisJo Anne Zujewski
Apr 4, 2009·Fertility and Sterility·Mikkel RosendahlAnders Nyboe Andersen
May 5, 2009·Fertility and Sterility·Ann H PartridgeElizabeth Ginsburg
Jun 4, 2010·The New England Journal of Medicine·Sandra M SwainNorman Wolmark
Dec 3, 2010·The New England Journal of Medicine·Sandra M SwainNorman Wolmark
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia A GanzSandra M Swain
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernd GerberUNKNOWN German Breast Group Investigators
Nov 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karolin BehringerPeter Borchmann
Dec 3, 2013·Endocrine-related Cancer·Claudia BozzaLucia Del Mastro
Mar 29, 2014·Breast Cancer Research and Treatment·Jianli ZhaoFengxi Su
Mar 19, 2015·Menopause : the Journal of the North American Menopause Society·Qiong ZhouJingsong Lu
May 20, 2015·Breast Cancer Research and Treatment·Kathryn J RuddySara M Tolaney
Dec 13, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Matteo LambertiniUNKNOWN MIG and GIM study groups
Aug 3, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sherko KümmelSibylle Loibl
Oct 20, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S LoiblM Untch
May 15, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael UntchSibylle Loibl
Sep 14, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hyun-Ah KimUNKNOWN Korean Breast Cancer Study Group
Oct 17, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Olivia PaganiUNKNOWN SOFT and TEXT Investigators and International Breast Cancer Study Group
Dec 7, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip D PoorvuAnn H Partridge
Sep 26, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LambertiniUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Dec 8, 2020·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org, UNKNOWN Practice Committee of the American Society for Reproductive Medicine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.