Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy

Journal of Clinical Gastroenterology
Waleed M AlazmiGlen L Lehman

Abstract

Hepatic arterial infusion of fluoropyrimidines has been widely used for the treatment of hepatic metastasis from colorectal cancer. One major complication of such treatment is biliary sclerosis resembling primary sclerosing cholangitis, which has an incidence ranging from 8% to 26%. We evaluated the efficacy and long-term outcome of endoscopic therapy in the management of chemotherapy-induced sclerosing cholangitis (CISC). With the use of an endoscopic retrograde cholangiopancreatography (ERCP) database, all patients with a diagnosis of CISC who had endoscopic therapy between March 1995 and March 2005 were identified. The indications, findings, therapies, and complications for all patients undergoing ERCP were recorded in this database. Additional information was obtained by review of medical records. Eleven patients (six men and five women) were identified. The mean age at presentation was 59.5 years (range, 36-76 years). Cholangiogram findings revealed stricture confined to the common hepatic duct in two patients, involving the hilum in seven patients, involving the right and/or left main hepatic ducts in nine patients, and extending to the intrahepatic radicals in two patients. All patients had successful endoscopic therapy ...Continue Reading

References

Jun 1, 1991·Gastroenterology·J M FarrantR Williams
Sep 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W J HrusheskyJ T Rabatin
Aug 1, 1985·Annals of Surgery·M M KemenyJ J Terz
Mar 15, 1984·Cancer·J E NiederhuberE Cozzi
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BrooméL S Eriksson
Jan 24, 2003·International Journal of Gastrointestinal Cancer·K T Barnett, M P Malafa
Feb 8, 2003·Lancet·David J KerrUNKNOWN European Organisation for Research and Treatment of Cancer colorectal cancer study group
Feb 13, 1964·The New England Journal of Medicine·R D SULLIVANE WATKINS
Jul 13, 2004·Cancer Treatment Reviews·Fedricker D BarberRazelle Kurzrock

❮ Previous
Next ❯

Citations

Apr 7, 2007·Current Opinion in Gastroenterology·James Rl Maggs, Roger W Chapman
Jul 19, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Christine O MeniasKedar N Chintapalli
Oct 9, 2013·Clinics in Liver Disease·Xuchen ZhangSwan N Thung
Jan 3, 2012·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Kai QuYa-min Liu
Apr 29, 2008·Journal of Vascular and Interventional Radiology : JVIR·Bassel AtassiRiad Salem
Nov 25, 2014·Abdominal Imaging·Pardeep K MittalWilliam C Small
Jul 1, 2015·Archives of Pathology & Laboratory Medicine·Yukihiro Nakanishi, Romil Saxena
Jun 23, 2011·Transplantation Proceedings·O UskudarC Chang
Nov 25, 2014·Virchows Archiv : an International Journal of Pathology·M Isabel FielThomas D Schiano
Jul 26, 2011·AJR. American Journal of Roentgenology·Alampady Krishna Prasad ShanbhogueMatthew McInnes
Apr 30, 2013·Case Reports in Gastroenterology·David Sicong FanRoberto Mauro Gamarra
Oct 18, 2019·ACG Case Reports Journal·Akira KusakabeKazuhiro Katayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.