PMID: 7026020Oct 1, 1981Paper

Chemotherapy of advanced breast cancer: a randomized trial of vincristine, Adriamycin, and cyclophosphamide (VAC) versus cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP)

Cancer
J Carmo-PereiraE Henriques

Abstract

Fifty-one patients with metastatic breast cancer were randomly allocated to receive either a four drug combination consisting of cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP), or a combination of vincristine, Adriamycin, and cyclophosphamide (VAC) with cross-over on relapse. Objective responses were seen in 17 of 26 patients (65%) in the CMFP group and in 14 of 25 patients (56%) in the VAC group, but this difference was not statistically significant. The median duration of response for each group was one year. The estimated median survival was greater for the CMFP group, but this was not significant. Toxicity was more severe with the VAC regimen. It is concluded that there is no therapeutic advantage of the VAC over the CMFP regimen.

References

Apr 1, 1976·Annals of Internal Medicine·G P CanellosR C Young

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Citations

Dec 1, 1985·Journal of Steroid Biochemistry·F CavalliK W Brunner
Mar 1, 1988·European Journal of Cancer & Clinical Oncology·J Carmo-PereiraA Sales-Luis
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FalksonH C Falkson
Oct 21, 2004·The Cochrane Database of Systematic Reviews·S LordJ Simes
Jan 1, 1984·Medical Oncology and Tumor Pharmacotherapy·L S Perlow, J F Holland

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