PMID: 15218423Jun 26, 2004Paper

Chemotherapy-related secondary acute myeloid leukemia in patients diagnosed with osteosarcoma

Journal of Pediatric Hematology/oncology
M Carmen EscuderoLuis Madero

Abstract

Secondary acute leukemia (SAL) after treatment of osteosarcoma has been seldom reported in children. Two main mechanisms that can induce SAL have been described. The authors describe two patients who developed SAL after treatment with multiagent therapy. The first patient developed a secondary acute leukemia after treatment with alkylating agents and platinum compounds. The second patient had the clinical and molecular features of a secondary acute leukemia due to topoisomerase II inhibitors. The authors also discuss the data regarding cisplatin-associated SAL. Different molecular and pathogenic agents may be implicated in the development of second malignant neoplasms in long-term survivors of osteosarcomas.

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Citations

Mar 5, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Alexandra J PopeMichael J Hannon
Dec 18, 2004·Current Opinion in Rheumatology·Jorge Casas-Ganem, John H Healey
Dec 24, 2005·Oncology·F ChristophM Schrader
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Dec 16, 2010·Cancer Genetics and Cytogenetics·Bella BieloraiAmos Toren
Nov 12, 2005·Pediatric Blood & Cancer·Ayhan DagdemirSabri Acar
Feb 8, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Katharina SeidensaalSemi B Harrabi
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

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