Chemotherapy Resistance Molecular Mechanism in Small Cell Lung Cancer

Current Molecular Medicine
Jun ZhouWei Song

Abstract

The malignancy of small cell lung cancer (SCLC) is the highest amongst all lung cancer types. It is characterized by rapid growth, early occurrence of distant sites metastasis, poor survival rates and is initially sensitive to chemotherapy and radiotherapy. However, most patients eventually relapse or disease progresses because of chemotherapy resistance. Because of lack of effective second-line therapies, the prognosis of SCLC patients is usually poor. For the development of novel therapies, it is necessary to understand the mechanisms of chemotherapy resistance in SCLC. The mechanism is complex, because multiple factors could lead to chemotherapy resistance. An overview of multiple events triggering the formation of chemotherapy resistance phenotypes of SCLC cells is discussed.

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Citations

Feb 4, 2021·Thoracic Cancer·Zsolt MegyesfalviBalazs Dome
Jul 22, 2021·Cell Biology International·Zhenhua ZhangJunjian Wang
Jun 11, 2021·Recent Patents on Anti-cancer Drug Discovery·Fuyuan ZhangDayun Sui
Dec 19, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying JinMing Chen

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