Chemotherapy response in East Asian non-small cell lung cancer patients harboring wild-type or activating mutation of epidermal growth factor receptors

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Chia-Chi LinTony S Mok

Abstract

Previous exploratory analysis of epidermal growth factor receptor (EGFR) mutational status in tumor samples from randomized clinical studies suggested that patients with activating mutation of the EGFR had better survival than those harboring wild-type EGFR. We analyzed the EGFR sequence of tumor samples from advanced stage non-small cell lung cancer patients previously participated in treatment clinical trials. Responses to chemotherapy and survival of EGFR mutation-positive or -negative patients were compared. Tumor samples from 122 patients were available for analysis. EGFR mutation was present in 58 patients (47.5%). In 105 stage IIIB/IV patients, there was a nonstatistically significant trend toward a higher chemotherapy response rate of patients with mutated EGFR than those with wild-type EGFR (44.6% versus 30.6%, p = 0.162). Female, never-smoking, and adenocarcinoma patients lived longer than male (p = 0.0139), smoking (p = 0.0045), or nonadenocarcinoma (p = 0.0151) patients. There was no difference in the survival of patients with mutated or wild-type EGFR (p = 0.2159). There was no difference in progression-free survival of first-line chemotherapy between patients with wild-type or mutation in EGFR (6.6 months versus 6...Continue Reading

References

May 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro FukuokaJosé Baselga
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GiacconeDavid H Johnson
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstDavid H Johnson
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sae-Won HanNoe Kyeong Kim
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tetsuya MitsudomiYasushi Yatabe
Apr 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sung-Hsin KuoPan-Chyr Yang
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshimi TakanoTomohide Tamura
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 27, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstUNKNOWN TRIBUTE Investigator Group
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daphne W BellDaniel A Haber
Jun 6, 2006·The Lancet Oncology·Fiona BlackhallNick Thatcher
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistDaniel A Haber
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ulrich GatzemeierJoachim Von Pawel
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chih-Hsin YangPan-Chyr Yang
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshimi TakanoTomohide Tamura
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R GandaraPhilip C Mack
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka

❮ Previous
Next ❯

Citations

Jul 10, 2012·Medical Oncology·Angela ZupaGiuseppina Improta
Jul 11, 2013·Future Oncology·Hsiang-Fong KaoJames Chih-Hsin Yang
Jul 22, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Qiong ZhangJun-Qing Han
Nov 29, 2011·Cancer Treatment Reviews·Jean-Charles SoriaPasi A Jänne
Jan 10, 2012·Environmental and Molecular Mutagenesis·Jing-Hua RenGang Wu
Aug 8, 2014·Journal of Cellular and Molecular Medicine·Luis Paz-AresBarbara Klughammer
Feb 14, 2014·Tuberculosis and Respiratory Diseases·Seung Hun Jang
Sep 14, 2018·American Journal of Clinical Oncology·Amanda J W GibsonWinson Y Cheung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.