Chemotherapy use in stage III colon cancer: a National Cancer Database analysis

Therapeutic Advances in Medical Oncology
Smrity UpadhyayPeter T Silberstein

Abstract

Although adjuvant chemotherapy in stage III colon cancer improves overall survival, prior studies have shown that it is underused. We analyzed different factors that may influence its use. This is a retrospective study of stage III colon cancer patients (n = 207,718) diagnosed between 2000 and 2011 in the National Cancer Data Base (NCDB). The NCDB contains ~70% of new cancer diagnosis from >1500 American College of Surgeons accredited cancer programs in the United States and Puerto Rico. The chi-squared test was used to determine any difference in characteristics of patients who did or did not receive chemotherapy. A total of 35% of all stage III colon cancer patients, and 38% of stage III cases undergoing surgery, did not receive adjuvant chemotherapy. The use of chemotherapy had increased in recent years (64% in 2007-2011 versus 59% in 2000-2002; p < 0.0001). Its use was lower in whites (61%), females (60%), patients ⩾60 years (55%), patients with one or more comorbidities (55%), nonacademic centers (62%), those with medicare insurance (52%), lower education (61%) and income levels (59%, all p < 0.0001). The nonwhite and uninsured were more likely to be <60 years old. More than one-third did not receive adjuvant chemotherapy,...Continue Reading

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Citations

May 13, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K ArakawaH Nozawa
Apr 12, 2019·International Journal of Cancer. Journal International Du Cancer·Enrico MiniStefania Nobili
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Dec 24, 2020·International Journal of Molecular Sciences·Luigi LaghiAlberto Malesci
Apr 12, 2021·The Journal of Surgical Research·Katherine A HrebinkoRichard S Hoehn

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Methods Mentioned

BETA
surgical resection

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