Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

The Cochrane Database of Systematic Reviews
Sarah L ColeridgeJ Morrison

Abstract

Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. However, there may be advantages to using chemotherapy before surgery. To assess whether there is an advantage to treating women with advanced epithelial ovarian cancer with chemotherapy before debulking surgery (neoadjuvant chemotherapy (NACT)) compared with conventional treatment where chemotherapy follows debulking surgery (primary debulking surgery (PDS)). We searched the following databases on 11 February 2019: CENTRAL, Embase via Ovid, MEDLINE (Silver Platter/Ovid), PDQ and MetaRegister. We also checked the reference lists of relevant papers that were identified to search for further studies. The main investigators of relevant trials were contacted for further information. Randomised controlled trials (RCTs) of women with advanced epithelial ovarian cancer (Federation of International Gynaecologists and Obstetricians (FIGO) stage III/IV) who were randomly allocated to treatment groups that compared platinum-based chemotherapy before cytoreductive surgery with platinum-based chemotherapy foll...Continue Reading

References

Dec 1, 1991·Gynecologic Oncology·E PetruR Jakse
Feb 1, 1991·Gynecologic Oncology·E BurghardtH Stettner
Jun 1, 1990·Gynecologic Oncology·J T ChambersP E Schwartz
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 1, 1994·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·D OsobaJ Latreille
Apr 1, 1994·Gynecologic Oncology·P E SchwartzR Makuch
Feb 1, 1994·British Journal of Obstetrics and Gynaecology·C W RedmanG R Blackledge
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·J T Lim, J A Green
Jan 1, 1996·Journal of Surgical Oncology·G SinghB V Muralikrishna
Jan 1, 1996·European Journal of Gynaecological Oncology·A OnnisL Castellan
Jan 16, 1999·Gynecologic Oncology·P E SchwartzR P Thiel
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M MuggiaJ M Small
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. SuzukiI. Sato
Sep 1, 1995·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. BrinkhuisJ.P.A. Baak
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert E BristowF J Montz
Mar 22, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F KayikçiogluG Tulunay
Jun 27, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E GreimelUNKNOWN EORTC Quality of Life Group and the Quality of Life Unit
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 8, 2003·Onkologie·J PfistererU Wagner
Dec 4, 2003·Journal of the American College of Surgeons·Philippe MoriceDamienne Castaigne
Nov 18, 2004·Journal of the National Cancer Institute·Paul A VaseyUNKNOWN Scottish Gynaecological Cancer Trials Group
Dec 14, 2004·The New England Journal of Medicine·Peter G RoseUNKNOWN Gynecologic Oncology Group
Mar 16, 2005·The Breast : Official Journal of the European Society of Mastology·V ShillingD Bloomfield
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·V LoizziL Selvaggi
Apr 21, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R F Ozols
May 21, 2005·Cancer Chemotherapy and Pharmacology·Tania DuttaNeeta Singh
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T BerghmansJ P Sculier
Sep 2, 2005·World Journal of Surgical Oncology·Mohamed A F HegazyAmal A F Halim
Mar 28, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Athanasios G PallisVassilis Georgoulias

❮ Previous
Next ❯

Citations

Apr 1, 2020·International Journal of Environmental Research and Public Health·Chen-Yu HuangPeng-Hui Wang
Nov 24, 2020·Aging·Tingting SunGuofen Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.