PMID: 11899035Mar 20, 2002Paper

Chemotherapy with cyclophosphamide, vincristine, and prednisolone (COP) in cats with malignant lymphoma: new results with an old protocol

Journal of Veterinary Internal Medicine
Erik TeskeGerard R Rutteman

Abstract

This retrospective study in 61 cats with malignant lymphomas examined the efficacy of a well-established chemotherapy protocol (cyclophosphamide, vincristine, and prednisolone [COP]) in the Netherlands, a country with a low prevalence of feline leukemia virus (FeLV). Twenty-two cats (36.1%) had mediastinal lymphoma, 11 (18.0%) had alimentary lymphoma, 7 (11.5%) had peripheral lymphoma, 8 (13.1%) had nasal lymphoma, and 13 (21.3%) had miscellaneous lymphoma (including renal lymphoma in 2 [3.3%]). Of the 54 cats that were tested, only 4 (7.4%) were FeLV positive. Complete remission (CR) was achieved in 46 of the 61 cats (75.4%). The estimated 1- and 2-year disease-free periods (DFPs) in the 46 cats with CR were 51.4 and 37.8%, respectively, whereas the median duration of remission was 251 days. The overall estimated 1-year survival rate in all cats was 48.7%, and the 2-year survival rate was 39.9%, with a median survival of 266 days. The median survival time and the 1-year survival rate for mediastinal lymphoma were 262 days and 49.4%. respectively. Siamese cats had a more favorable prognosis for survival and remission than other breeds. Response to therapy in this study was shown to be a significant prognostic indicator. CR is n...Continue Reading

Citations

Mar 4, 2008·Journal of Veterinary Internal Medicine·D SimonI Nolte
Jan 16, 2009·Journal of Veterinary Internal Medicine·S M HaneyC Azuma
Feb 5, 2008·Journal of the American Veterinary Medical Association·Michael A KiselowHollis N Erb
Apr 4, 2013·Journal of the American Veterinary Medical Association·Angharad H K WaiteErika L Krick
Mar 16, 2005·Journal of Virology·Alfred L RocaStephen J O'Brien
Dec 4, 2012·Viruses·Katrin Hartmann
Apr 14, 2011·The Veterinary Clinics of North America. Small Animal Practice·Tracy Gieger
Mar 10, 2016·Journal of the American Veterinary Medical Association·Lauren KmieciakStephen Joslyn
Apr 13, 2013·The Journal of General Virology·Sayumi ShimodeTakayuki Miyazawa
Apr 19, 2016·The Journal of Veterinary Medical Science·Dah-Renn FuTsuyoshi Kadosawa
Dec 21, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dominique A RamirezDaniel L Gustafson

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