Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use

Drugs
J H Iser, A Sali

Abstract

Chenodeoxycholic acid (chenic acid; CDCA) is 1 of the 3 major biliary bile acids in man. When administered in pharmacological doses it causes a decrease in cholesterol saturation of bile, which in turn may lead to gradual dissolution of cholesterol gallstones. The stone dissolution rate during CDCA therapy has varied considerably from about one-third of patients overall to 80 to 90% in a highly selected group of patients. Radiolucent gallstones in a functioning gallbladder are absolute requirements. CDCA is well tolerated; diarrhoea (sometimes requiring dosage reduction) is the only frequent side effect. Although hepatotoxicity has occurred in certain animal species, and slight hypertransaminasaemia has occurred in some patients, definite liver damage has not been observed in man. CDCA is considered contraindicated in pregnancy, and in those patients with the complications from gallstones which require immediate surgery. Care should be taken in patients with liver disease. The only other proven agent for dissolving gallstones is the 7 beta-epimer of CDCA, ursodeoxycholic acid (UDCA). Preliminary results show that UDCA is as effective as CDCA, but at one-half to two-thirds the dose, without causing diarrhoea. Further studies nee...Continue Reading

Citations

Feb 1, 1986·Drug Intelligence & Clinical Pharmacy·M A Abate
Apr 1, 1985·Postgraduate Medical Journal·K W SomervilleG D Bell
Mar 10, 2018·Beilstein Journal of Organic Chemistry·Fabio Tonin, Isabel W C E Arends
Apr 3, 2019·Journal of Clinical Biochemistry and Nutrition·Teruo MiyazakiYasushi Matsuzaki
Mar 1, 1992·Gut·R P JazrawiT C Northfield
Dec 1, 1988·Drug Intelligence & Clinical Pharmacy·C L Rosenbaum, R J Cluxton
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A F Hofmann
Dec 24, 2002·The Journal of Biological Chemistry·Isabelle DussaultBarry M Forman
Sep 20, 2005·Current Gastroenterology Reports·Bruce W Robb, Jeffrey B Matthews
Dec 14, 2004·The Journal of Biological Chemistry·Jiali LiStefan K Westin
May 18, 2004·The Journal of Clinical Investigation·Mitsuhiro WatanabeJohan Auwerx
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Manhal IzzySury Anand
Dec 12, 2012·Expert Opinion on Investigational Drugs·Banny S Wong, Michael Camilleri
Jul 25, 2014·Therapeutic Advances in Gastroenterology·Andres Acosta, Michael Camilleri
Mar 15, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Naoki IkedaMitsunori Seki
Feb 9, 2021·Biochemical Pharmacology·Yiming YinLili Chen
Jul 23, 1999·Archives of Biochemistry and Biophysics·M HofmannU Leuschner
May 11, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Daisuke YamaguchiMotohiro Esaki
Jan 1, 1983·Pharmacology & Therapeutics·G D Bell
May 1, 1984·Biotechnology and Bioengineering·G CarreaR Lodi
Jan 1, 1994·The American Journal of the Medical Sciences·G Broughton
Aug 31, 2021·Expert Opinion on Therapeutic Patents·Yuan KongDong-Dong Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.