Chest CT for triage during COVID-19 on the emergency department: myth or truth?

Emergency Radiology
Joep J R HermansVanessa Brown

Abstract

We aimed to investigate the diagnostic performance of chest CT compared with first RT-PCR results in adult patients suspected of COVID-19 infection in an ED setting. We also constructed a predictive machine learning model based on chest CT and additional data to improve the diagnostic accuracy of chest CT. This study's cohort consisted of 319 patients who underwent chest CT and RT-PCR testing at the ED. Patient characteristics, demographics, symptoms, vital signs, laboratory tests, and chest CT results (CO-RADS) were collected. With first RT-PCR as reference standard, the diagnostic performance of chest CT using the CO-RADS score was assessed. Additionally, a predictive machine learning model was constructed using logistic regression. Chest CT, with first RT-PCR as a reference, had a sensitivity, specificity, PPV, and NPV of 90.2%, 88.2%, 84.5%, and 92.7%, respectively. The prediction model with CO-RADS, ferritin, leucocyte count, CK, days of complaints, and diarrhea as predictors had a sensitivity, specificity, PPV, and NPV of 89.3%, 93.4%, 90.8%, and 92.3%, respectively. Chest CT, using the CO-RADS scoring system, is a sensitive and specific method that can aid in the diagnosis of COVID-19, especially if RT-PCR tests are scar...Continue Reading

References

Jan 30, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Victor M CormanChristian Drosten
Feb 6, 2020·Radiology·Michael ChungHong Shan
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Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
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Apr 28, 2020·Radiology·Mathias ProkopUNKNOWN COVID-19 Standardized Reporting Working Group of the Dutch Radiological Society

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Citations

Mar 17, 2021·The Cochrane Database of Systematic Reviews·Nayaar IslamUNKNOWN Cochrane COVID-19 Diagnostic Test Accuracy Group
Apr 1, 2021·Scientific Reports·Cedric GangloffMarc Cuggia
May 27, 2021·Applied Nanoscience·Ameer Sardar Kwekha-RashidBilal Alhayani
Jun 22, 2021·Journal of the American Medical Informatics Association : JAMIA·Yi GuoJiang Bian

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Methods Mentioned

BETA
X-ray
PCR

Software Mentioned

SPSS
learn
scikit

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