Chest radiographic abnormalities in HIV-infected African children: a longitudinal study

Thorax
Richard D PitcherHeather J Zar

Abstract

There is limited knowledge of chest radiographic abnormalities over time in HIV-infected children in resource-limited settings. To investigate the natural history of chest radiographic abnormalities in HIV-infected African children, and the impact of antiretroviral therapy (ART). Prospective longitudinal study of the association of chest radiographic findings with clinical and immunological parameters. Chest radiographs were performed at enrolment, 6-monthly, when initiating ART and if indicated clinically. Radiographic abnormalities were classified as normal, mild or moderate severity and considered persistent if present for 6 consecutive months or longer. An ordinal multiple logistic regression model assessed the association of enrolment and time-dependent variables with temporal radiographic findings. 258 children (median (IQR) age: 28 (13-51) months; median CD4+%: 21 (15-24)) were followed for a median of 24 (18-42) months. 70 (27%) were on ART at enrolment; 130 (50%) (median age: 33 (18-56) months) commenced ART during the study. 154 (60%) had persistent severe radiographic abnormalities, with median duration 18 (6-24) months. Among children on ART, 69% of radiographic changes across all 6-month transition periods were imp...Continue Reading

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Citations

Dec 16, 2016·The Pediatric Infectious Disease Journal·Engi F AttiaMichael H Chung
Sep 9, 2020·The Pediatric Infectious Disease Journal·Penelope K EllisPaul J Collini
Nov 23, 2019·The Lancet Child & Adolescent Health·Kathryn J SnowKatharina Kranzer
Nov 25, 2020·Pediatric Clinics of North America·Leah Githinji, Heather J Zar

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