Chest trauma and its impact on the release of vasoactive mediators

Shock
F GebhardU B Brückner

Abstract

Every year, major chest injury is involved in 56% of deaths in trauma victims. Blunt chest trauma apparently plays a crucial role in trauma-induced death of multiply injured patients. Therefore, the aim of this study was to evaluate the impact of different types of injuries, including lung tissue damage, on the release of various prostanoids. In a prospective study, the release of arachidonic acid (AA) metabolites was estimated in patients suffering blunt chest trauma alone, i.e., single thoracic injury, and in multiple injured patients including blunt chest trauma. The results were compared with those of patients suffering from single long bone fractures of the leg without additional injury. The plasma concentrations of the AA metabolites, prostacyclin, thromboxane, prostaglandin F2 alpha, and prostaglandin M were determined immediately after admission and in hourly and daily intervals thereafter. Despite clearly different injury scores, elevated levels of circulating AA metabolites were found in the plasma in all patients. This study reveals that any trauma increases significantly the release of prostanoids into the peripheral blood without regard to the impact of tissue damage. This phenomenon is, however, most pronounced fo...Continue Reading

Citations

Apr 16, 2010·Langenbeck's Archives of Surgery·Ulrich C LienerMarkus W Knöferl
Nov 20, 2003·Shock·Ulrich C LienerFlorian Gebhard
Dec 25, 2010·Journal of Applied Physiology·Elizabeth L CuretonGregory P Victorino
Jul 27, 1999·The Journal of Trauma·I CernakM Jevtic
Aug 19, 1999·The Journal of Trauma·W StreckerL Kinzl
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefan RecknagelAnita Ignatius
Nov 25, 2003·Der Unfallchirurg·T EinsiedelF Gebhard
Apr 14, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Uta KerkwegHerbert de Groot

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